Reactome | ATP13A4,5 transport divalent ions from extracellular region to cytosol

ATP13A4,5 transport divalent ions from extracellular region to cytosol

Stable Identifier

R-HSA-5251989

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

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ATP13A4,5 transport divalent ions from extracellular region to cytosol

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Probable cation-transporting ATPases 13A4 and 13A5 (ATP13A4, 5) belong to the P5 subfamily of P-tpre ATPases. This subfamily is the most poorly understood in terms of chracterisation and function. The yeast orthologue YPK9 (aka Yor291w) shows toxicity when deleted from yeast cells, suggesting a role in sequestration of divalent heavy metal ions (Schmidt et al. 2009). The ATP13A4 gene may be disrupted by a 3q25-q29 inversion of the long arm of chromosome 3, which may result in a specific language impairment (SLI) (Kwasnicka-Crawford et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15925480	Characterization of a novel cation transporter ATPase gene (ATP13A4) interrupted by 3q25-q29 inversion in an individual with language delay Kwasnicka-Crawford, DA, Carson, AR, Rehnström, K, Roberts, W, Summers, AM, Järvelä, I, Scherer, SW	Genomics	2005
19345671	Cd2+, Mn2+, Ni2+ and Se2+ toxicity to Saccharomyces cerevisiae lacking YPK9p the orthologue of human ATP13A2 Schmidt, K, Stiller, B, Pearce, DA, Wolfe, DM	Biochem. Biophys. Res. Commun.	2009