Reactome | PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane

PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane

Stable Identifier

R-HSA-1676065

Type

Reaction [transition]

Species

Homo sapiens

Compartment

late endosome membrane, cytosol

ReviewStatus

5/5

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PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane

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At the late endosome membrane, myotubularin (MTM1), myotubularin-related protein 2 (MTMR2), myotubularin-related protein 4 (MTMR4), and myotubularin-related protein 7 (MTMR7) dephosphorylate phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 5-phosphate (PI5P).

The following lists the above proteins with their corresponding literature references: MTM1 (Cao et al. 2007, Cao et al. 2008, Tsujita et al. 2004, Tronchere et al. 2004), MTMR2 (Cao et al. 2008), MTMR4 (Lorenzo et al. 2006), and MTMR7 (Mochizuki & Majerus 2003, Lorenzo et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
12890864	Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9 Mochizuki, Y, Majerus, PW	Proc Natl Acad Sci U S A	2003
16787938	Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions Lorenzo, O, Urbé, S, Clague, MJ	J Cell Sci	2006
14722070	Myotubularin regulates the function of the late endosome through the gram domain-phosphatidylinositol 3,5-bisphosphate interaction Tsujita, K, Itoh, T, Ijuin, T, Yamamoto, A, Shisheva, A, Laporte, J, Takenawa, T	J Biol Chem	2004
18524850	Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking Cao, C, Backer, JM, Laporte, J, Bedrick, EJ, Wandinger-Ness, A	Mol Biol Cell	2008
14660569	Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells Tronchère, H, Laporte, J, Pendaries, C, Chaussade, C, Liaubet, L, Pirola, L, Mandel, JL, Payrastre, B	J Biol Chem	2004
17651088	Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes Cao, C, Laporte, J, Backer, JM, Wandinger-Ness, A, Stein, MP	Traffic	2007