PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane

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R-HSA-1676065
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Reaction [transition]
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Homo sapiens
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At the late endosome membrane, myotubularin (MTM1), myotubularin-related protein 2 (MTMR2), myotubularin-related protein 4 (MTMR4), and myotubularin-related protein 7 (MTMR7) dephosphorylate phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 5-phosphate (PI5P).

The following lists the above proteins with their corresponding literature references: MTM1 (Cao et al. 2007, Cao et al. 2008, Tsujita et al. 2004, Tronchere et al. 2004), MTMR2 (Cao et al. 2008), MTMR4 (Lorenzo et al. 2006), and MTMR7 (Mochizuki & Majerus 2003, Lorenzo et al. 2006).

Literature References
PubMed ID Title Journal Year
16787938 Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions

Lorenzo, O, Urbé, S, Clague, MJ

J Cell Sci 2006
12890864 Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9

Mochizuki, Y, Majerus, PW

Proc Natl Acad Sci U S A 2003
14722070 Myotubularin regulates the function of the late endosome through the gram domain-phosphatidylinositol 3,5-bisphosphate interaction

Tsujita, K, Itoh, T, Ijuin, T, Yamamoto, A, Shisheva, A, Laporte, J, Takenawa, T

J Biol Chem 2004
18524850 Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking

Cao, C, Backer, JM, Laporte, J, Bedrick, EJ, Wandinger-Ness, A

Mol Biol Cell 2008
14660569 Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells

Tronchère, H, Laporte, J, Pendaries, C, Chaussade, C, Liaubet, L, Pirola, L, Mandel, JL, Payrastre, B

J Biol Chem 2004
17651088 Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes

Cao, C, Laporte, J, Backer, JM, Wandinger-Ness, A, Stein, MP

Traffic 2007
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Title
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity of MTM1,MTMR2,MTMR4,MTMR7 [cytosol]
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