ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells

Stable Identifier
R-HSA-9750656
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, extracellular region
Synonyms
ABCC2, ABCC3 transport salicylate metabolites out of hepatic cells
ReviewStatus
5/5
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ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells
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ATP-binding cassette sub-family C members 2 and 3 (ABCC2, ABCC3) transport glucuronides out of liver and kidney cells. They also are able to transport organic anions and amino acid conjugates (Cui et al, 1999; Zelcer et al, 2001; Järvinen, 2019).
Literature References
PubMed ID Title Journal Year
  Principles of Renal Physiology

Lote, CJ

  2000
10220572 Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells

Cui, Y, König, J, Buchholz, JK, Spring, H, Leier, I, Keppler, D

Mol Pharmacol 1999
11581266 Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3)

Zelcer, N, Saeki, T, Reid, G, Beijnen, JH, Borst, P

J Biol Chem 2001
  Human Efflux Transporters in Drug Disposition : in vitro Transport of Glucuronide Metabolites

Järvinen, E

   
Participants
Input
Output
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as an event of
Catalyst Activity

ABC-type transporter activity of ABCC2, ABCC3 [plasma membrane]

Physical Entity
ABCC2, ABCC3 [plasma membrane] (Homo sapiens)
Activity
ABC-type transporter activity (GO:0140359)
Orthologous Events
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Bos taurus)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Caenorhabditis elegans)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Canis familiaris)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Danio rerio)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Dictyostelium discoideum)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Drosophila melanogaster)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Gallus gallus)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Mus musculus)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Rattus norvegicus)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Saccharomyces cerevisiae)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Schizosaccharomyces pombe)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Sus scrofa)
ABCC2, ABCC3 transport salicylate metabolites from cytosol to extracellular region of hepatic cells (Xenopus tropicalis)
Authored
Stephan, R  (2021-08-09)
Reviewed
Huddart, R  (2021-10-13)
Created
Stephan, R  (2021-08-16)
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