phosphocreatine + H2O => creatinine + orthophosphate

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic phosphocreatine spontaneously hydrolyzes to yield creatinine and orthophosphate (Borsook and Dubnoff 1947). Creatinine cannot be metabolized further and is excreted from the body in the urine. Creatinine formation proceeds at a nearly constant rate and the amount produced by an individual is a function of muscle mass, so urinary creatinine output is clinically useful as a normalization factor in assays of urinary output of other molecules. Iyengar et al. (1985) have suggested that an alternative reaction sequence, proceeding via phosphocreatinine but also spontaneous, may contribute to creatinine formation.

Literature References
PubMed ID Title Journal Year
20238607 The hydrolysis of phosphocreatine and the origin of urinary creatinine

Dubnoff, JW, Borsook, H

J Biol Chem 1947
3997888 Phosphocreatinine, a high-energy phosphate in muscle, spontaneously forms phosphocreatine and creatinine under physiological conditions

Iyengar, MR, Butler, TM, Coleman, DW

J Biol Chem 1985
Cite Us!