NSF ATPase activity dissociates cis-SNARE at the ER

Stable Identifier
R-HSA-6811422
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
ReviewStatus
5/5
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NSF ATPase activity dissociates cis-SNARE at the ER
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NSF-dependent hydrolysis of ATP is required to disassociate the cis-SNARE complex, releasing the SNAREs for further rounds of membrane fusion (Mayer et al, 1996; Muller et al, 1999; Muller et al, 2002; Otto et al, 1997; Whiteheart et al, 2004; Yu et al, 1999; Zhao et al, 2012; Shah et al, 2015; reviewed in Sudhof and Rothman, 2009).
Literature References
PubMed ID Title Journal Year
8620540 Sec18p (NSF)-driven release of Sec17p (alpha-SNAP) can precede docking and fusion of yeast vacuoles

Mayer, A, Wickner, W, Haas, A

Cell 1996
9177194 Assembly and disassembly of a ternary complex of synaptobrevin, syntaxin, and SNAP-25 in the membrane of synaptic vesicles

Otto, H, Hanson, PI, Jahn, R

Proc. Natl. Acad. Sci. U.S.A. 1997
25492864 Three ?SNAP and 10 ATP molecules are used in SNARE complex disassembly by N-ethylmaleimide-sensitive factor (NSF)

Shah, N, Colbert, KN, Enos, MD, Herschlag, D, Weis, WI

J. Biol. Chem. 2015
10445031 NSF N-terminal domain crystal structure: models of NSF function

Yu, RC, Jahn, R, Brunger, AT

Mol. Cell 1999
15037235 Multiple binding proteins suggest diverse functions for the N-ethylmaleimide sensitive factor

Whiteheart, SW, Matveeva, EA

J. Struct. Biol. 2004
19164740 Membrane fusion: grappling with SNARE and SM proteins

Südhof, TC, Rothman, JE

Science 2009
21689688 Requirements for the catalytic cycle of the N-ethylmaleimide-Sensitive Factor (NSF)

Zhao, C, Smith, EC, Whiteheart, SW

Biochim. Biophys. Acta 2012
10559959 An NSF function distinct from ATPase-dependent SNARE disassembly is essential for Golgi membrane fusion

Müller, JM, Rabouille, C, Newman, R, Shorter, J, Freemont, P, Schiavo, G, Warren, G, Shima, DT

Nat. Cell Biol. 1999
12070132 Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion

Muller, JM, Shorter, J, Newman, R, Deinhardt, K, Sagiv, Y, Elazar, Z, Warren, G, Shima, DT

J. Cell Biol. 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ATP hydrolysis activity of SEC22B:STX18:USE1:BNIP1L:3xSNAPs:NSF hexamer [endoplasmic reticulum membrane]

Physical Entity
SEC22B:STX18:USE1:BNIP1L:3xSNAPs:NSF hexamer [endoplasmic reticulum membrane] (Homo sapiens)
Activity
ATP hydrolysis activity (GO:0016887)
Authored
Rothfels, K  (2015-11-09)
Reviewed
Gillespie, ME  (2016-02-02)
Created
Rothfels, K  (2015-11-19)
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