PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane

Stable Identifier
R-HSA-6809325
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Formation of a complex with MTMR9 results in a 4-fold increase of the phosphatidylinositol-3-phosphatase catalytic activity of MTMR8 and a modest increase of the catalytic activity of MTMR6 (Zou et al. 2012).
Literature References
PubMed ID Title Journal Year
22647598 Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8

Zou, J, Zhang, C, Marjanovic, J, Kisseleva, MV, Majerus, PW, Wilson, MP

Proc. Natl. Acad. Sci. U.S.A. 2012
Participants
Input
Output
Participates
as an event of
Catalyst Activity

phosphatidylinositol-3-phosphate phosphatase activity of MTMR6:MTMR9,MTMR8:MTMR9 [cytosol]

Physical Entity
MTMR6:MTMR9,MTMR8:MTMR9 [cytosol] (Homo sapiens)
Activity
phosphatidylinositol-3-phosphate phosphatase activity (GO:0004438)
Orthologous Events
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Bos taurus)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Caenorhabditis elegans)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Canis familiaris)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Danio rerio)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Drosophila melanogaster)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Gallus gallus)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Mus musculus)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Rattus norvegicus)
PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane (Sus scrofa)
Cross References
RHEA
Authored
Orlic-Milacic, M  (2015-11-13)
Reviewed
Rush, MG  (2017-01-10)
Created
Orlic-Milacic, M  (2015-11-11)
Cite Us!