ATP13A1 transports Mn2+ from cytosol to ER lumen

Stable Identifier
R-HSA-5692462
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane, endoplasmic reticulum lumen
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ATP13A1 transports Mn2+ from cytosol to ER lumen
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Manganese-transporting ATPase 13A1 (ATP13A1) mediates the transport of manganese (Mn2+) into the endoplasmic reticulum. ATPase activity is required for cellular manganese homeostasis (Cohen et al. 2013).
Literature References
PubMed ID Title Journal Year
24392018 The yeast p5 type ATPase, spf1, regulates manganese transport into the endoplasmic reticulum

Cohen, Y, Megyeri, M, Chen, OC, Condomitti, G, Riezman, I, Loizides-Mangold, U, Abdul-Sada, A, Rimon, N, Riezman, H, Platt, FM, Futerman, AH, Schuldiner, M

PLoS ONE 2013
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ABC-type manganese transporter activity of ATP13A1 [endoplasmic reticulum membrane]

Physical Entity
ATP13A1 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
ABC-type manganese transporter activity (GO:0015410)
Orthologous Events
ATP13A1 transports Mn2+ from cytosol to ER lumen (Bos taurus)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Caenorhabditis elegans)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Canis familiaris)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Danio rerio)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Dictyostelium discoideum)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Drosophila melanogaster)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Gallus gallus)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Mus musculus)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Plasmodium falciparum)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Rattus norvegicus)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Saccharomyces cerevisiae)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Schizosaccharomyces pombe)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Sus scrofa)
ATP13A1 transports Mn2+ from cytosol to ER lumen (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2015-05-12)
Reviewed
D'Eustachio, P  (2015-06-26)
Created
Jassal, B  (2015-05-12)
Cite Us!