Reactome | MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met

MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met

Stable Identifier

R-HSA-5603114

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

AdoMet is sythesized from methionine's reaction with ATP

ReviewStatus

5/5

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MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met

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S-adenosylmethionine (AdoMet, SAM) is an essential metabolite in all cells. AdoMet is a precursor in the synthesis of polyamines. Methionine adenosyltransferases (MAT) catalyse the only known AdoMet biosynthetic reaction from methionine (L-Met) and ATP. In mammalian tissues, three different forms of MAT (MAT I, MAT III and MAT II) have been identified that are the product of two different genes (MAT1A and MAT2A). A third gene, MAT2B has been identified and its protein product is known to associate as a regulatory subunit with catalytic MAT2A (LeGros et al. 2000, Halim et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
10514445	Expression and functional interaction of the catalytic and regulatory subunits of human methionine adenosyltransferase in mammalian cells Halim, AB, LeGros, L, Geller, A, Kotb, M	J. Biol. Chem.	1999
10644686	Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II) Halim, AB, Geller, AM, LeGros, HL, Kotb, M	J. Biol. Chem.	2000