Inactivation of R-Ras by Sema3A-Plexin-A1 GAP activity

Stable Identifier
R-MMU-421142
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Inactivation of R-Ras by Sema3A-Plexin-A1 GAP activity
Plexin-A's are GAPs for the Ras family GTPase R-Ras. On stimulation with Rnd-1, plexin-A directly and specifically down regulates R-Ras activity. R-Ras activity is critical for PI3K activation and ECM-mediated beta1 integrin activation and cell migration. Inactivation of R-Ras by Sema3A/Plexin-A1 reduces integrin-mediated adhesions. It has been suggested that the final step in the Sema3A repulsive signaling pathway is inhibition of integrin activity. Reduced integrin activity allows detachment from the substratum and subsequent cell retraction.
Literature References
PubMed ID Title Journal Year
11108845 The semaphorin 3A receptor may directly regulate the activity of small GTPases

Rohm, B, Rahim, B, Kleiber, B, Hovatta, I, Püschel, AW

FEBS Lett 2000
Participants
Input
Output
Catalyst Activity

GTPase activator activity of Sema3A:pPlexin-A1:Neuropilin-1:Rac1-GTP:Rnd1 [plasma membrane]

Physical Entity
Sema3A:pPlexin-A1:Neuropilin-1:Rac1-GTP:Rnd1 [plasma membrane] (Mus musculus)
Activity
GTPase activator activity (GO:0005096)
Orthologous Events
Inactivation of R-Ras by Sema3A-Plexin-A GAP activity (Homo sapiens)
Authored
Garapati, P V  (2009-03-23)
Reviewed
Kumanogoh, A  (2009-09-02)
Kikutani, H  (2009-09-02)
Created
Garapati, P V  (2009-05-15)
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