Reactome | ABCB4 transports PC from plasma membrane to extracellular region

ABCB4 transports PC from plasma membrane to extracellular region

Stable Identifier

R-HSA-5678706

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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ABCB4 transports PC from plasma membrane to extracellular region

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Multidrug resistance protein 3 (ATP-binding cassette sub-family B member 4, ABCB4 aka MDR3) mediates the ATP-dependent export of organic anions and drugs from hepatocytes into the canalicular lumen in the presence of bile salts. ABCB4 is especially important for the export of phospholipids such as phosphatidylcholine (PC) from the plasma membrane of hepatocytes (Morita et al. 2007). Biliary phospholipids associate with bile salts and cholesterol in mixed micelles, thereby reducing the detergent activity and cytotoxicity of bile salts and preventing cholesterol crystallisation. Thus, ABCB4 plays a crucial role in bile formation and lipid homeostasis (Morita & Terada 2014).

Literature References

PubMed ID	Title	Journal	Year
17523162	Bile salt-dependent efflux of cellular phospholipids mediated by ATP binding cassette protein B4 Kioka, N, Matsuo, M, Morita, SY, Kobayashi, A, Arai, H, Takanezawa, Y, Handa, T, Ueda, K	Hepatology	2007
25133187	Molecular mechanisms for biliary phospholipid and drug efflux mediated by ABCB4 and bile salts Terada, T, Morita, SY	Biomed Res Int	2014