ABCB4 transports PC from plasma membrane to extracellular region

Stable Identifier
Reaction [transition]
Homo sapiens
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Multidrug resistance protein 3 (ATP-binding cassette sub-family B member 4, ABCB4 aka MDR3) mediates the ATP-dependent export of organic anions and drugs from hepatocytes into the canalicular lumen in the presence of bile salts. ABCB4 is especially important for the export of phospholipids such as phosphatidylcholine (PC) from the plasma membrane of hepatocytes (Morita et al. 2007). Biliary phospholipids associate with bile salts and cholesterol in mixed micelles, thereby reducing the detergent activity and cytotoxicity of bile salts and preventing cholesterol crystallisation. Thus, ABCB4 plays a crucial role in bile formation and lipid homeostasis (Morita & Terada 2014).

Literature References
PubMed ID Title Journal Year
17523162 Bile salt-dependent efflux of cellular phospholipids mediated by ATP binding cassette protein B4

Kioka, N, Matsuo, M, Morita, SY, Kobayashi, A, Arai, H, Takanezawa, Y, Handa, T, Ueda, K

Hepatology 2007
25133187 Molecular mechanisms for biliary phospholipid and drug efflux mediated by ABCB4 and bile salts

Terada, T, Morita, SY

Biomed Res Int 2014
Catalyst Activity

phospholipid transporter activity of ABCB4 [plasma membrane]

Orthologous Events
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