Reactome | SGPP1,2 dephosphorylate sphingoid-1-phosphates

SGPP1,2 dephosphorylate sphingoid-1-phosphates

Stable Identifier

R-HSA-428664

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

sphinganine 1-phosphate + H2O => sphinganine + orthophosphate

ReviewStatus

5/5

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SGPP1,2 dephosphorylate sphingoid-1-phosphates

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SGPP1 and 2 (sphingosine-1-phosphate phosphatase 1 and 2) enzymes associated with the endoplasmic reticulum membrane catalyze the hydrolysis of cytosolic sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. to form sphinganine (dihydrosphingosine, phytosphingosine) and orthophosphate. Availability of sphingoids versus sphingoid-1-phosphates has direct influence on all processes involving ceramides (Johnson et al. 2003; Ogawa et al. 2003; Giussani et al., 2006).

Literature References

PubMed ID	Title	Journal	Year
16782891	Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide Maceyka, M, Wang, E, Mikami, A, Giussani, P, Merrill, AH, Milstien, S, Kelly, S, Le Stunff, H, Lépine, S, Spiegel, S	Mol Cell Biol	2006
12411432	Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2 Ogawa, C, Gokoh, M, Igarashi, Y, Kihara, A	J Biol Chem	2003
12815058	Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability Mao, C, Johnson, KR, Bielawski, J, Obeid, LM, Becker, KP, Johnson, KY	J Biol Chem	2003