SGPP1,2 dephosphorylate sphingoid-1-phosphates

Stable Identifier
R-HSA-428664
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
sphinganine 1-phosphate + H2O => sphinganine + orthophosphate
ReviewStatus
5/5
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SGPP1 and 2 (sphingosine-1-phosphate phosphatase 1 and 2) enzymes associated with the endoplasmic reticulum membrane catalyze the hydrolysis of cytosolic sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. to form sphinganine (dihydrosphingosine, phytosphingosine) and orthophosphate. Availability of sphingoids versus sphingoid-1-phosphates has direct influence on all processes involving ceramides (Johnson et al. 2003; Ogawa et al. 2003; Giussani et al., 2006).
Literature References
PubMed ID Title Journal Year
16782891 Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide

Maceyka, M, Wang, E, Mikami, A, Giussani, P, Merrill, AH, Milstien, S, Kelly, S, Le Stunff, H, L├ępine, S, Spiegel, S

Mol Cell Biol 2006
12411432 Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2

Ogawa, C, Gokoh, M, Igarashi, Y, Kihara, A

J Biol Chem 2003
12815058 Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability

Mao, C, Johnson, KR, Bielawski, J, Obeid, LM, Becker, KP, Johnson, KY

J Biol Chem 2003
Participants
Participates
Catalyst Activity

sphingosine-1-phosphate phosphatase activity of SGPP [endoplasmic reticulum membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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