glyceraldehyde 3-phosphate + NAD+ + phosphate <=> 1,3-bisphosphoglycerate + NADH + H+

Stable Identifier
R-GGA-352956
Type
Reaction [transition]
Species
Gallus gallus
Compartment
cytosol
Synonyms
Dehydrogenation of glyceraldehyde 3-phosphate to form 1,3-bisphosphoglycerate
ReviewStatus
5/5
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glyceraldehyde 3-phosphate + NAD+ + phosphate <=> 1,3-bisphosphoglycerate + NADH + H+
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Cytosolic GAPDH catalyzes the reversible reaction of glyceraldehyde 3-phosphate, NAD+, and phosphate to form 1,3-bisphosphoglycerate and NADH + H+. The active form of the enzyme is a homotetramer (Allison and Kaplan 1964; Dugaiczyk et al. 1983).

Literature References
PubMed ID Title Journal Year
6303388 Cloning and sequencing of a deoxyribonucleic acid copy of glyceraldehyde-3-phosphate dehydrogenase messenger ribonucleic acid isolated from chicken muscle

Dugaiczyk, A, Rothblum, KN, Dennison, OE, Schwartz, RJ, Stone, EM, Haron, JA

Biochemistry 1983
14209940 The comparative enzymology of triophosphate dehydrogenase

Kaplan, NO, Allison, WS

J Biol Chem 1964
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Catalyst Activity

glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity of GAPDH tetramer [cytosol]

Physical Entity
GAPDH tetramer [cytosol] (Gallus gallus)
Activity
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity (GO:0004365)
Authored
D'Eustachio, P  (2008-09-10)
Reviewed
Harris, RA  (2008-09-10)
Created
D'Eustachio, P  (2008-06-09)
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