Reactome | TTLL3, TTLL8, TTLL10 polyglycylate tubulin

TTLL3, TTLL8, TTLL10 polyglycylate tubulin

Stable Identifier

R-HSA-8867370

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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TTLL3, TTLL8, TTLL10 polyglycylate tubulin

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Tubulin is modified by glutamylation and glycylation, the additon of peptide branches made of glutamyl or glycyl residues respectively, which are attached to the gamma-carboxyl group of glutamic acids within the C-terminal tail domains of alpha- and beta-tubulin. They are added by members of the tubulin tyrosine ligase (TTL family). TTLL3, 8, and 10 are glycylases (Ikegami et al. 2008, Ikegami and Setou, 2009; Rogowski et al. 2009; Wloga et al. 2009) with TTLL3 and 8 serving as initiases, and TTLL10 serving as an elongase. In this event polyglycation is arbitrarily shown on only one tubulin protofilament within the microtubule.

Literature References

PubMed ID	Title	Journal	Year
19531357	TTLL3 Is a tubulin glycine ligase that regulates the assembly of cilia Gaertig, J, Webster, DM, Jerka-Dziadosz, M, Bré, MH, Levilliers, N, Rogowski, K, Janke, C, Dougan, ST, Wloga, D	Dev. Cell	2009
19524510	Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation Gaertig, J, Thomas, D, Bré, MH, Levilliers, N, Strub, JM, van Dorsselaer, A, Rogowski, K, Janke, C, van Dijk, J, Wloga, D, Juge, F	Cell	2009
18331838	TTLL10 is a protein polyglycylase that can modify nucleosome assembly protein 1 Mukai, M, Setou, M, Horigome, D, Livnat, I, Macgregor, GR, Ikegami, K	FEBS Lett.	2008