Reactome | SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites

SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites

Stable Identifier

R-HSA-9668419

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, nuclear envelope

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The AAA+ ATPase activity of spastin (SPAST) removes attached microtubules from chromosomes, allowing formation of a sealed nuclear envelope (Vietri et al. 2015, Ventimiglia et al. 2018).

Literature References

PubMed ID	Title	Journal	Year
30513301	CC2D1B Coordinates ESCRT-III Activity during the Mitotic Reformation of the Nuclear Envelope Ventimiglia, LN, Cuesta-Geijo, MA, Martinelli, N, Caballe, A, Macheboeuf, P, Miguet, N, Parnham, IM, Olmos, Y, Carlton, JG, Weissenhorn, W, Martin-Serrano, J	Dev. Cell	2018
26040712	Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing Vietri, M, Schink, KO, Campsteijn, C, Wegner, CS, Schultz, SW, Christ, L, Thoresen, SB, Brech, A, Raiborg, C, Stenmark, H	Nature	2015