The AAA+ ATPase activity of spastin (SPAST) removes attached microtubules from chromosomes, allowing formation of a sealed nuclear envelope (Vietri et al. 2015, Ventimiglia et al. 2018).
Vietri, M, Schink, KO, Campsteijn, C, Wegner, CS, Schultz, SW, Christ, L, Thoresen, SB, Brech, A, Raiborg, C, Stenmark, H
Ventimiglia, LN, Cuesta-Geijo, MA, Martinelli, N, Caballe, A, Macheboeuf, P, Miguet, N, Parnham, IM, Olmos, Y, Carlton, JG, Weissenhorn, W, Martin-Serrano, J
microtubule-severing ATPase activity of LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope]
© 2021 Reactome