SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites

Stable Identifier
R-HSA-9668419
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The AAA+ ATPase activity of spastin (SPAST) removes attached microtubules from chromosomes, allowing formation of a sealed nuclear envelope (Vietri et al. 2015, Ventimiglia et al. 2018).

Literature References
PubMed ID Title Journal Year
26040712 Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

Vietri, M, Schink, KO, Campsteijn, C, Wegner, CS, Schultz, SW, Christ, L, Thoresen, SB, Brech, A, Raiborg, C, Stenmark, H

Nature 2015
30513301 CC2D1B Coordinates ESCRT-III Activity during the Mitotic Reformation of the Nuclear Envelope

Ventimiglia, LN, Cuesta-Geijo, MA, Martinelli, N, Caballe, A, Macheboeuf, P, Miguet, N, Parnham, IM, Olmos, Y, Carlton, JG, Weissenhorn, W, Martin-Serrano, J

Dev. Cell 2018
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
microtubule-severing ATPase activity of LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope]
Physical Entity
Activity
Orthologous Events
Authored
Created