Reactome | SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites

SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites

Stable Identifier

R-HSA-9668419

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, nuclear envelope

ReviewStatus

5/5

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SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites

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The AAA+ ATPase activity of spastin (SPAST) removes attached microtubules from chromosomes, allowing formation of a sealed nuclear envelope (Vietri et al. 2015, Ventimiglia et al. 2018).

Literature References

PubMed ID	Title	Journal	Year
30513301	CC2D1B Coordinates ESCRT-III Activity during the Mitotic Reformation of the Nuclear Envelope Olmos, Y, Cuesta-Geijo, MA, Ventimiglia, LN, Carlton, JG, Miguet, N, Macheboeuf, P, Weissenhorn, W, Parnham, IM, Martinelli, N, Caballe, A, Martin-Serrano, J	Dev. Cell	2018
26040712	Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing Campsteijn, C, Schultz, SW, Schink, KO, Wegner, CS, Brech, A, Christ, L, Raiborg, C, Thoresen, SB, Stenmark, H, Vietri, M	Nature	2015