Reactome | SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites

SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites

Stable Identifier

R-HSA-9668419

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, nuclear envelope

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SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites

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The AAA+ ATPase activity of spastin (SPAST) removes attached microtubules from chromosomes, allowing formation of a sealed nuclear envelope (Vietri et al. 2015, Ventimiglia et al. 2018).

Literature References

PubMed ID	Title	Journal	Year
26040712	Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing Vietri, M, Schink, KO, Campsteijn, C, Wegner, CS, Schultz, SW, Christ, L, Thoresen, SB, Brech, A, Raiborg, C, Stenmark, H	Nature	2015
30513301	CC2D1B Coordinates ESCRT-III Activity during the Mitotic Reformation of the Nuclear Envelope Ventimiglia, LN, Cuesta-Geijo, MA, Martinelli, N, Caballe, A, Macheboeuf, P, Miguet, N, Parnham, IM, Olmos, Y, Carlton, JG, Weissenhorn, W, Martin-Serrano, J	Dev. Cell	2018