Phosphorylated BSK kinase is dephosphorylated and deactivated by PUC phosphatase

Stable Identifier
R-DME-209157
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
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The JUN kinase phosphatase Puckered (PUC) dephosphorylates and consequently deactivates the phosphorylated Basket (BSK) kinase. The gene that encodes PUC is a target of the AP-1 transcription factor making this interaction part of a regulatory negative feedback loop.

Literature References
PubMed ID Title Journal Year
9472024 puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila

Martin-Blanco, E, Gampel, A, Ring, J, Virdee, K, Kirov, N, Tolkovsky, AM, Martinez-Arias, A

Genes Dev 1998
Participants
Participates
Catalyst Activity

JUN kinase phosphatase activity of PUC [cytosol]

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Reviewed
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