Phosphorylated BSK kinase is dephosphorylated and deactivated by PUC phosphatase

Stable Identifier
R-DME-209157
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
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Phosphorylated BSK kinase is dephosphorylated and deactivated by PUC phosphatase
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The JUN kinase phosphatase Puckered (PUC) dephosphorylates and consequently deactivates the phosphorylated Basket (BSK) kinase. The gene that encodes PUC is a target of the AP-1 transcription factor making this interaction part of a regulatory negative feedback loop.
Literature References
PubMed ID Title Journal Year
9472024 puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila

Martinez-Arias, A, Tolkovsky, AM, Gampel, A, Ring, J, Virdee, K, Kirov, N, Martin-Blanco, E

Genes Dev 1998
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Catalyst Activity

JUN kinase phosphatase activity of PUC [cytosol]

Physical Entity
PUC [cytosol] (Drosophila melanogaster)
Activity
JUN kinase phosphatase activity (GO:0008579)
Authored
Williams, MG  (2007-07-11)
Reviewed
Lemaitre, B  (2008-06-20)
Silverman, N  (2008-06-20)
Created
Williams, MG  (2007-07-12)
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