Dephosphorylation of Gab1 by SHP2

Stable Identifier
R-HSA-177924
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Phosphorylated GAB1 can bind PI3 kinase by its regulatory alpha subunit. SHP2 dephosphorylation of the tyrosine residues 447, 472 and 589 on GAB1 means PI3 kinase can no longer bind to the complex in the plasma membrane and cannot be activated.

Literature References
PubMed ID Title Journal Year
10734310 Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis

Gual, P, Giordano, S, Williams, TA, Rocchi, S, Van Obberghen, E, Comoglio, PM

Oncogene 2000
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
non-membrane spanning protein tyrosine phosphatase activity of EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created