eIF5B:GTP is hydrolyzed and released

Stable Identifier
R-HSA-72671
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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eIF5B:GTP is hydrolyzed and released
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Once the 60S subunit joins the translation initiation complex, eIF5B hydrolyzes its GTP and is released from the now 80S monosome. The fully assembled 80s ribosome is now ready to start elongation of the polypeptide chain.
Literature References
PubMed ID Title Journal Year
1095581 Purification and characterization of homogeneous initiation factor M2A from rabbit reticulocytes.

Merrick, WC, Kemper, WM, Anderson, WF

J Biol Chem 1975
10659855 The joining of ribosomal subunits in eukaryotes requires eIF5B.

Pestova, TV, Lomakin, IB, Lee, JH, Choi, SK, Dever, TE, Hellen, CU

Nature 2000
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Orthologous Events
eIF5B:GTP is hydrolyzed and released (Bos taurus)
eIF5B:GTP is hydrolyzed and released (Caenorhabditis elegans)
eIF5B:GTP is hydrolyzed and released (Canis familiaris)
eIF5B:GTP is hydrolyzed and released (Dictyostelium discoideum)
eIF5B:GTP is hydrolyzed and released (Drosophila melanogaster)
eIF5B:GTP is hydrolyzed and released (Gallus gallus)
eIF5B:GTP is hydrolyzed and released (Mus musculus)
eIF5B:GTP is hydrolyzed and released (Plasmodium falciparum)
eIF5B:GTP is hydrolyzed and released (Rattus norvegicus)
eIF5B:GTP is hydrolyzed and released (Saccharomyces cerevisiae)
eIF5B:GTP is hydrolyzed and released (Schizosaccharomyces pombe)
eIF5B:GTP is hydrolyzed and released (Sus scrofa)
eIF5B:GTP is hydrolyzed and released (Xenopus tropicalis)
Created
Merrick, WC  (2002-12-16)
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