Reactome | ATP4A:ATP4B exchanges K+ for H+

ATP4A:ATP4B exchanges K+ for H+

Stable Identifier

R-HSA-9727198

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

Synonyms

The K+-transporting ATPase mediates the exchange of potassium and hydrogen ions

ReviewStatus

5/5

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The potassium-transporting ATPase heterodimer comprising a catalytic alpha and stabilising beta chain (ATP4A:ATP4B), catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. The human gene ATP4A encodes the catalytic alpha subunit (Maeda et al. 1990). One human gene encodes the beta subunit, ATP4B (Ma et al. 1991). ATP4A is responsible for acid production in the stomach.

Literature References

PubMed ID	Title	Journal	Year
2160952	Human gastric (H+ + K+)-ATPase gene. Similarity to (Na+ + K+)-ATPase genes in exon/intron organization but difference in control region Maeda, M, Oshiman, K, Tamura, S, Futai, M	J Biol Chem	1990
1656976	cDNA cloning of the beta-subunit of the human gastric H,K-ATPase Ma, JY, Song, YH, Sjöstrand, SE, Rask, L, Mårdh, S	Biochem Biophys Res Commun	1991