ATP4A:ATP4B exchanges K+ for H+

Stable Identifier
R-HSA-9727198
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
The K+-transporting ATPase mediates the exchange of potassium and hydrogen ions
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The potassium-transporting ATPase heterodimer comprising a catalytic alpha and stabilising beta chain (ATP4A:ATP4B), catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. The human gene ATP4A encodes the catalytic alpha subunit (Maeda et al. 1990). One human gene encodes the beta subunit, ATP4B (Ma et al. 1991). ATP4A is responsible for acid production in the stomach.

Literature References
PubMed ID Title Journal Year
2160952 Human gastric (H+ + K+)-ATPase gene. Similarity to (Na+ + K+)-ATPase genes in exon/intron organization but difference in control region

Oshiman, K, Maeda, M, Futai, M, Tamura, S

J Biol Chem 1990
1656976 cDNA cloning of the beta-subunit of the human gastric H,K-ATPase

Song, YH, Mårdh, S, Ma, JY, Rask, L, Sjöstrand, SE

Biochem Biophys Res Commun 1991
Participants
Participates
Catalyst Activity

P-type potassium:proton transporter activity of ATP4A:ATP4B [plasma membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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