Reactome | PTEN dephosphorylates PIP3

PTEN dephosphorylates PIP3

Stable Identifier

R-HSA-199456

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Synonyms

PI(3,4,5)P3 is dephosphorylated to PI (4,5)P2 by PTEN at the plasma membrane

ReviewStatus

5/5

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At the plasma membrane, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase aka phosphatase and tensin homolog (PTEN) dephosphorylates phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) (Maehama & Dixon 1998, Myers et al. 1998, Das et al. 2003). The PI3K network is negatively regulated by phospholipid phosphatases that dephosphorylate PIP3, thus hampering AKT activation (Myers et al. 1998). The tumour suppressor PTEN is the primary phospholipid phosphatase.
Early studies indicated that magnesium ion, Mg2+, was needed for the catalytic activity of PTEN isolated from bovine thymus (Kabuyama et al. 1996). Subsequent studies have shown that PTEN was catalytically active in buffers free of magnesium and magnesium was not detected as part of the PTEN crystal (Lee et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
10555148	Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association Georgescu, MM, Pavletich, NP, Shi, Y, Maehama, T, Pandolfi, P, Yang, H, Lee, JO, Dixon, JE, Di Cristofano, A	Cell	1999
12808147	Membrane-binding and activation mechanism of PTEN Das, S, Cho, W, Dixon, JE	Proc Natl Acad Sci U S A	2003
9593664	The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate Dixon, JE, Maehama, T	J Biol Chem	1998
9811831	The lipid phosphatase activity of PTEN is critical for its tumor supressor function Stolarov, JP, van der Kaay, J, Myers, MP, Pass, I, Downes, CP, Batty, IH, Wigler, MH, Tonks, NK, Hemmings, BA	Proc Natl Acad Sci U S A	1998
8681945	Purification and characterization of the phosphatidylinositol-3,4,5-trisphosphate phosphatase in bovine thymus Fukui, Y, Kabuyama, Y, Homma, Y, Nakatsu, N	Eur. J. Biochem.	1996