Reactome | (d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)

(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)

Stable Identifier

R-HSA-109380

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)

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Cytosolic 5'-nucleotidase IA (NT5C1A) catalyzes the hydrolysis of (deoxy)cytidine monophosphate, thymidine monophosphate and (deoxy)uridine monophosphate to the corresponding nucleosides plus orthophosphate. The enzyme is allosterically activated by ADP (Hunsucker et al. 2001). The human enzyme is inferred to be a homotetramer with one Mg++ ion bound per subunit based on its similarity to the pigeon heart enzyme (Bianchi and Spychala 2003; Sala-Newby et al. 1999; Skladanowski and Newby 1990).

Literature References

PubMed ID	Title	Journal	Year
11133996	Human cytosolic 5'-nucleotidase I. Characterization and role in nucleoside analog resistance Hunsucker, SA, Spychala, J, Mitchell, BS	J Biol Chem	2001
10364222	The mechanism of adenosine formation in cells. Cloning of cytosolic 5'-nucleotidase-I Skladanowski, A, Newby, AC, Sala-Newby, GB	J Biol Chem	1999
12947102	Mammalian 5'-nucleotidases Spychala, J, Bianchi, V	J Biol Chem	2003
2344353	Partial purification and properties of an AMP-specific soluble 5'-nucleotidase from pigeon heart Skladanowski, A, Newby, AC	Biochem J	1990