RHOF GAPs stimulate RHOF GTPase activity

Stable Identifier
R-HSA-9693282
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The following GTPase activating proteins (GAPs) were shown to bind RHOF and stimulate its GTPase activity, resulting in GTP to GDP hydrolysis and conversion of the active RHOF:GTP complex into the inactive RHOF:GDP complex (the study by Bagci et al. 2020 reported binding of GAPs to active RHOF without testing for RHOF-directed GAP activity and is cited as a supporting evidence):
ARHGAP1 (Amin et al. 2016; supported by Bagci et al. 2020)

The following candidate RHOF GAPs were reported by Bagci et al. 2020 to bind active RHOF, but their RHOF-directed GAP activity has not been tested:
ARHGAP5 (Bagci et al. 2020)
ARHGAP12 (Bagci et al. 2020)
ARHGAP21 (Bagci et al. 2020)
ARHGAP32 (Bagci et al. 2020)
ARHGAP39 (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
MYO9B (Bagci et al. 2020)
PIK3R1 (Bagci et al. 2020)
PIK3R2 (Bagci et al. 2020)
SRGAP2 (Bagci et al. 2020)
SYDE1 (Bagci et al. 2020)

The following GAPs were reported to not act on RHOF or were reported by Bagci et al. 2020 to not bind active RHOF without testing of theirr RHOF-directed GAP activity:
ABR (Amin et al. 2016; Bagci et al. 2020)
ARAP2 (Bagci et al. 2020)
ARAP3 (Bagci et al. 2020)
ARHGAP17 (Amin et al. 2016; Bagci et al. 2020)
ARHGAP26 (Amin et al. 2016)
ARHGAP29 (Bagci et al. 2020)
ARHGAP31 (Bagci et al. 2020)
ARHGAP35 (Amin et al. 2016); Bagci et al. 2020)
ARHGAP42 (Bagci et al. 2020)
BCR (Bagci et al. 2020)
DLC1 (Amin et al. 2016)
MYO9A (Bagci et al. 2020)
OCRL (Lichter Konecki et al. 2006; Erdmann et al. 2007; Bagci et al. 2020)
OPHN1 (Amin et al. 2016; Bagci et al. 2020)
RACGAP1 (Amin et al. 2016; Bagci et al. 2020)
STARD13 (Amin et al. 2016)
STARD8 (Amin et al. 2016)

Literature References
PubMed ID Title Journal Year
17765681 A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway

Erdmann, KS, Mao, Y, McCrea, HJ, Zoncu, R, Lee, S, Paradise, S, Modregger, J, Biemesderfer, D, Toomre, D, De Camilli, P

Dev. Cell 2007
27481945 Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS

Amin, E, Jaiswal, M, Derewenda, U, Reis, K, Nouri, K, Koessmeier, KT, Aspenström, P, Somlyo, AV, Dvorsky, R, Ahmadian, MR

J. Biol. Chem. 2016
16777452 The effect of missense mutations in the RhoGAP-homology domain on ocrl1 function

Lichter-Konecki, U, Farber, LW, Cronin, JS, Suchy, SF, Nussbaum, RL

Mol. Genet. Metab. 2006
31871319 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

Bagci, H, Sriskandarajah, N, Robert, A, Boulais, J, Elkholi, IE, Tran, V, Lin, ZY, Thibault, MP, Dubé, N, Faubert, D, Hipfner, DR, Gingras, AC, Cote, JF

Nat. Cell Biol. 2020
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Catalyst Activity

GTPase activator activity of RHOF GAPs [cytosol]

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