Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate

Stable Identifier
R-HSA-176606
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PAP is generated as a byproduct of sulfonation reactions in vivo; its hydrolysis to AMP and orthophosphate returns its constituents to the pool of molecules available for cytosolic nucleotide metabolism. Bisphosphate 3'-nucleotidase 1catalyzes this reaction efficiently in vitro; whether other nucleotidases also play a role in PAP breakdown in vivo is unknown.

Literature References
PubMed ID Title Journal Year
10224133 Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate

Spiegelberg, BD, Xiong, JP, Smith, JJ, Gu, RF, York, JD

J Biol Chem 1999
Participants
Participates
Event Information
Catalyst Activity

3'(2'),5'-bisphosphate nucleotidase activity of BPNT1 [cytosol]

Orthologous Events
Cross References
Rhea
Created
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