Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate

Stable Identifier
R-HSA-176606
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PAP is generated as a byproduct of sulfonation reactions in vivo; its hydrolysis to AMP and orthophosphate returns its constituents to the pool of molecules available for cytosolic nucleotide metabolism. Bisphosphate 3'-nucleotidase 1catalyzes this reaction efficiently in vitro; whether other nucleotidases also play a role in PAP breakdown in vivo is unknown.
Literature References
PubMed ID Title Journal Year
10224133 Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate

Spiegelberg, BD, Xiong, JP, Smith, JJ, Gu, RF, York, JD

J Biol Chem 1999
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Event Information
Go Biological Process
3'-phosphoadenosine 5'-phosphosulfate metabolic process (0050427)
Catalyst Activity

3'(2'),5'-bisphosphate nucleotidase activity of BPNT1 [cytosol]

Physical Entity
BPNT1 [cytosol] (Homo sapiens)
Activity
3'(2'),5'-bisphosphate nucleotidase activity (GO:0008441)
Orthologous Events
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Bos taurus)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Caenorhabditis elegans)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Canis familiaris)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Danio rerio)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Dictyostelium discoideum)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Drosophila melanogaster)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Gallus gallus)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Mus musculus)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Rattus norvegicus)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Sus scrofa)
Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate (Xenopus tropicalis)
Cross References
RHEA
Created
D'Eustachio, P  (2006-03-09)
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