Reactome | Inactivation of LCK by PTPN22

Inactivation of LCK by PTPN22

Stable Identifier

R-HSA-8852200

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Synonyms

Inactivation of LCK by LYP

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Protein tyrosine phosphatase PTPN22 (LYP, PEP) (Cohen et al. 1999) dephosphorylates tyrosine residue Y394 of LCK, thus inactivating LCK and down-regulating TCR signaling (Wu et al. 2006, Vang et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
16461343	Identification of substrates of human protein-tyrosine phosphatase PTPN22 Wu, J, Katrekar, A, Honigberg, LA, Smith, AM, Conn, MT, Tang, J, Jeffery, D, Mortara, K, Sampang, J, Williams, SR, Buggy, J, Clark, JM	J. Biol. Chem.	2006
22426112	LYP inhibits T-cell activation when dissociated from CSK Vang, T, Liu, WH, Delacroix, L, Wu, S, Vasile, S, Dahl, R, Yang, L, Musumeci, L, Francis, D, Landskron, J, Tasken, K, Tremblay, ML, Lie, BA, Page, R, Mustelin, T, Rahmouni, S, Rickert, RC, Tautz, L	Nat. Chem. Biol.	2012