Inactivation of LCK by PTPN22

Stable Identifier
R-HSA-8852200
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Synonyms
Inactivation of LCK by LYP
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Inactivation of LCK by PTPN22
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Protein tyrosine phosphatase PTPN22 (LYP, PEP) (Cohen et al. 1999) dephosphorylates tyrosine residue Y394 of LCK, thus inactivating LCK and down-regulating TCR signaling (Wu et al. 2006, Vang et al. 2012).

Literature References
PubMed ID Title Journal Year
16461343 Identification of substrates of human protein-tyrosine phosphatase PTPN22

Wu, J, Katrekar, A, Honigberg, LA, Smith, AM, Conn, MT, Tang, J, Jeffery, D, Mortara, K, Sampang, J, Williams, SR, Buggy, J, Clark, JM

J. Biol. Chem. 2006
22426112 LYP inhibits T-cell activation when dissociated from CSK

Vang, T, Liu, WH, Delacroix, L, Wu, S, Vasile, S, Dahl, R, Yang, L, Musumeci, L, Francis, D, Landskron, J, Tasken, K, Tremblay, ML, Lie, BA, Page, R, Mustelin, T, Rahmouni, S, Rickert, RC, Tautz, L

Nat. Chem. Biol. 2012
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine phosphatase activity of PTPN22 [cytosol]
Physical Entity
PTPN22 [cytosol]
Activity
protein tyrosine phosphatase activity (0004725)
Orthologous Events
Inactivation of LCK by PTPN22 (Bos taurus)
Inactivation of LCK by PTPN22 (Canis familiaris)
Inactivation of LCK by PTPN22 (Mus musculus)
Inactivation of LCK by PTPN22 (Rattus norvegicus)
Inactivation of LCK by PTPN22 (Sus scrofa)
Inactivation of LCK by PTPN22 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-02-03)
Reviewed
Stanford, S  (2016-05-10)
Bottini, N  (2016-05-10)
Created
Orlic-Milacic, M  (2016-01-14)