Reactome | PI3P is dephosphorylated to PI by MTM1:MTMR12

PI3P is dephosphorylated to PI by MTM1:MTMR12

Stable Identifier

R-HSA-6809720

Type

Reaction [transition]

Species

Homo sapiens

Compartment

early endosome membrane, cytosol

ReviewStatus

5/5

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PI3P is dephosphorylated to PI by MTM1:MTMR12

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Binding of MTMR12 to MTM1 enhances phosphatidylinositol-3-phosphatase activity of MTM1 at cytosolic vesicular structures, presumably early or late endosomes (Caldwell et al. 1991, Nandurkar et al. 2003, Gupta et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23818870	Loss of catalytically inactive lipid phosphatase myotubularin-related protein 12 impairs myotubularin stability and promotes centronuclear myopathy in zebrafish Gupta, VA, Hnia, K, Smith, LL, Gundry, SR, McIntire, JE, Shimazu, J, Bass, JR, Talbot, EA, Amoasii, L, Goldman, NE, Laporte, J, Beggs, AH	PLoS Genet.	2013
1655747	Isolation and characterization of two 3-phosphatases that hydrolyze both phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate Caldwell, KK, Lips, DL, Bansal, VS, Majerus, PW	J. Biol. Chem.	1991
12847286	Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP Nandurkar, HH, Layton, M, Laporte, J, Selan, C, Corcoran, L, Caldwell, KK, Mochizuki, Y, Majerus, PW, Mitchell, CA	Proc. Natl. Acad. Sci. U.S.A.	2003