PI3P is dephosphorylated to PI by MTM1:MTMR12

Stable Identifier
Reaction [transition]
Homo sapiens
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Binding of MTMR12 to MTM1 enhances phosphatidylinositol-3-phosphatase activity of MTM1 at cytosolic vesicular structures, presumably early or late endosomes (Caldwell et al. 1991, Nandurkar et al. 2003, Gupta et al. 2013).

Literature References
PubMed ID Title Journal Year
23818870 Loss of catalytically inactive lipid phosphatase myotubularin-related protein 12 impairs myotubularin stability and promotes centronuclear myopathy in zebrafish

Gundry, SR, Gupta, VA, Smith, LL, Shimazu, J, McIntire, JE, Talbot, EA, Goldman, NE, Beggs, AH, Amoasii, L, Laporte, J, Hnia, K, Bass, JR

PLoS Genet. 2013
1655747 Isolation and characterization of two 3-phosphatases that hydrolyze both phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate

Majerus, PW, Lips, DL, Caldwell, KK, Bansal, VS

J. Biol. Chem. 1991
12847286 Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP

Corcoran, L, Majerus, PW, Mitchell, CA, Selan, C, Layton, M, Mochizuki, Y, Caldwell, KK, Laporte, J, Nandurkar, HH

Proc. Natl. Acad. Sci. U.S.A. 2003
Catalyst Activity

phosphatidylinositol-3-phosphatase activity of MTM1:MTMR12 [cytosol]

Orthologous Events
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