PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane

Stable Identifier
R-HSA-1676005
Type
Reaction
Species
Homo sapiens
Compartment
Golgi membrane, cytosol
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PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane
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At the Golgi membrane, the PAS complex, consisting of FYVE finger-containing phosphoinositide kinase (PIKFYVE), yeast VAC14 homologue (VAC14), and polyphosphoinositide phosphatase aka SAC3 (FIG4), binds to the membrane via PIKFYVE's FYVE finger. The FIG4 phosphatase component dephosphorylates phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 3-phosphate (PI3P) (Sbrissa et al. 2007, Sbrissa et al. 2008).

Literature References
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Output
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as an event of
Catalyst Activity

phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity of PIKFYVE:VAC14:FIG4 [Golgi membrane]

Physical Entity
PIKFYVE:VAC14:FIG4 [Golgi membrane] (Homo sapiens)
Activity
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity (GO:0043813)
Orthologous Events
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Canis familiaris)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Gallus gallus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Mus musculus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Rattus norvegicus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Sus scrofa)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Xenopus tropicalis)
Cross References
Rhea
Authored
Williams, MG  (2011-10-18)
Reviewed
Wakelam, M  (2012-05-14)
Created
Williams, MG  (2011-10-17)
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