PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane

Stable Identifier
R-HSA-1676005
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the Golgi membrane, the PAS complex, consisting of FYVE finger-containing phosphoinositide kinase (PIKFYVE), yeast VAC14 homologue (VAC14), and polyphosphoinositide phosphatase aka SAC3 (FIG4), binds to the membrane via PIKFYVE's FYVE finger. The FIG4 phosphatase component dephosphorylates phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 3-phosphate (PI3P) (Sbrissa et al. 2007, Sbrissa et al. 2008).

Literature References
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity of PIKFYVE:VAC14:FIG4 [Golgi membrane]
Physical Entity
PIKFYVE:VAC14:FIG4 [Golgi membrane]
Activity
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity (0043813)
Orthologous Events
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Canis familiaris)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Gallus gallus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Mus musculus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Rattus norvegicus)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Sus scrofa)
PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the Golgi membrane (Xenopus tropicalis)
Authored
Williams, MG  (2011-10-18)
Reviewed
Wakelam, M  (2012-05-14)
Created
Williams, MG  (2011-10-17)