Reactome | PPA1 hydrolyzes pyrophosphate to orthophosphate

PPA1 hydrolyzes pyrophosphate to orthophosphate

Stable Identifier

R-HSA-71732

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

pyrophosphate + H2O => 2 orthophosphate [cytosolic]

ReviewStatus

5/5

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PPA1 hydrolyzes pyrophosphate to orthophosphate

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Cytosolic PPA1 (pyrophosphatase (inorganic) 1) catalyzes the hydrolysis of pyrophosphate to yield two molecules of orthophosphate. The enzyme, a homodimer, requires Mg++ for activity (Fisher et al. 1974; Pynes and Younathan 1967; Thuiller et al. 1978).

Literature References

PubMed ID	Title	Journal	Year
4130389	Studies on human erythrocyte inorganic pyrophosphatase. Harris, H, Dorkin, HL, Fisher, RA, Turner, BM	Ann Hum Genet	1974
656444	Purification and kinetic properties of human erythrocyte Mg2+-dependent inorganic pyrophosphatase Thuillier, L	Biochim Biophys Acta	1978
6022858	Purification and some properties of inorganic pyrophosphatase from human erythrocytes Younathan, ES, Pynes, GD	J Biol Chem	1967