pyrophosphate + H2O => 2 orthophosphate [cytosolic]

Stable Identifier
R-HSA-71732
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic PPA1 (pyrophosphatase (inorganic) 1) catalyzes the hydrolysis of pyrophosphate to yield two molecules of orthophosphate. The enzyme, a homodimer, requires Mg++ for activity (Fisher et al. 1974; Pynes and Younathan 1967; Thuiller et al. 1978).

Literature References
PubMed ID Title Journal Year
656444 Purification and kinetic properties of human erythrocyte Mg2+-dependent inorganic pyrophosphatase

Thuillier, L

Biochim Biophys Acta 1978
4130389 Studies on human erythrocyte inorganic pyrophosphatase.

Fisher, RA, Turner, BM, Dorkin, HL, Harris, H

Ann Hum Genet 1974
6022858 Purification and some properties of inorganic pyrophosphatase from human erythrocytes

Pynes, GD, Younathan, ES

J Biol Chem 1967
Participants
Output
Participant Of
Catalyst Activity
Catalyst Activity
Title
inorganic diphosphatase activity of PPA1 dimer [cytosol]
Physical Entity
Activity
This event is regulated
Orthologous Events
Cross References
Rhea
Cite Us!