Adenylate cyclase increases the GTPase activity of G alpha-olf

Stable Identifier
R-HSA-170666
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Adenylate cyclase increases the GTPase activity of G alpha-olf
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G proteins can deactivate themselves via their intrinsic GTPase activity, which hydrolyzes GTP to GDP. Effectors such as adenylate cyclase can increase the G protein GTPase rate, acting like GTPase-activating proteins (GAPs).
Literature References
PubMed ID Title Journal Year
7937899 Mechanism of GTP hydrolysis by G-protein alpha subunits

Kleuss, C, Raw, AS, Lee, E, Sprang, SR, Gilman, AG

Proc Natl Acad Sci U S A 1994
Participants
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Output
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as an event of
Catalyst Activity

GTPase activity of (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane]

Physical Entity
(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
Activity
GTPase activity (GO:0003924)
Orthologous Events
Adenylate cyclase increases the GTPase activity of G alpha-olf (Bos taurus)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Caenorhabditis elegans)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Canis familiaris)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Danio rerio)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Dictyostelium discoideum)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Drosophila melanogaster)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Gallus gallus)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Mus musculus)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Rattus norvegicus)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Sus scrofa)
Adenylate cyclase increases the GTPase activity of G alpha-olf (Xenopus tropicalis)
Authored
Le Novere, N  (2004-03-31)
Jassal, B  (2004-03-31)
Reviewed
Castagnoli, L  (2008-11-06)
Created
Jassal, B  (2006-01-10)
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