Along with PPP5C-mediated dephophosphorylation of the NtA region, PP2A contributes to the inactivation of RAF1 by mediating the dephosphorylation of AL loop residues. PP2A-mediated dephosphorylation of RAF1 may be stimulated by the prior hyperphosphorylation of RAF1 by MAPKs (Dougherty et al, 2005; reviewed in Matallanas et al, 2011).
Zhou, XZ, Veenstra, TD, Dougherty, MK, Lu, KP, Müller, J, Copeland, TD, Zhou, M, Morrison, DK, Conrads, TP, Ritt, DA
Romano, D, Matallanas, D, Rauch, J, Zebisch, A, Birtwistle, M, Kolch, W, von Kriegsheim, A
protein serine/threonine phosphatase activity of PP2A [cytosol]
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