PP2A dephosphorylates RAF1

Stable Identifier
R-HSA-5675431
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
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PP2A dephosphorylates RAF1
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Along with PPP5C-mediated dephophosphorylation of the NtA region, PP2A contributes to the inactivation of RAF1 by mediating the dephosphorylation of AL loop residues. PP2A-mediated dephosphorylation of RAF1 may be stimulated by the prior hyperphosphorylation of RAF1 by MAPKs (Dougherty et al, 2005; reviewed in Matallanas et al, 2011).

Literature References
PubMed ID Title Journal Year
21779496 Raf family kinases: old dogs have learned new tricks

Matallanas, D, Birtwistle, M, Romano, D, Zebisch, A, Rauch, J, von Kriegsheim, A, Kolch, W

Genes Cancer 2011
15664191 Regulation of Raf-1 by direct feedback phosphorylation

Dougherty, MK, Müller, J, Ritt, DA, Zhou, M, Zhou, XZ, Copeland, TD, Conrads, TP, Veenstra, TD, Lu, KP, Morrison, DK

Mol. Cell 2005
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine phosphatase activity of PP2A [cytosol]
Physical Entity
PP2A [cytosol]
Activity
protein serine/threonine phosphatase activity (0004722)
This event is regulated
Positively by
Orthologous Events
PP2A dephosphorylates RAF1 (Danio rerio)
PP2A dephosphorylates RAF1 (Dictyostelium discoideum)
PP2A dephosphorylates RAF1 (Gallus gallus)
PP2A dephosphorylates RAF1 (Mus musculus)
PP2A dephosphorylates RAF1 (Rattus norvegicus)
PP2A dephosphorylates RAF1 (Xenopus tropicalis)
Authored
Rothfels, K  (2015-02-16)
Reviewed
Roskoski, R Jr  (2015-04-29)
Created
Rothfels, K  (2015-02-16)