PP2A dephosphorylates RAF1

Stable Identifier
R-HSA-5675431
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Along with PPP5C-mediated dephophosphorylation of the NtA region, PP2A contributes to the inactivation of RAF1 by mediating the dephosphorylation of AL loop residues. PP2A-mediated dephosphorylation of RAF1 may be stimulated by the prior hyperphosphorylation of RAF1 by MAPKs (Dougherty et al, 2005; reviewed in Matallanas et al, 2011).
Literature References
PubMed ID Title Journal Year
15664191 Regulation of Raf-1 by direct feedback phosphorylation

Zhou, XZ, Veenstra, TD, Dougherty, MK, Lu, KP, Müller, J, Copeland, TD, Zhou, M, Morrison, DK, Conrads, TP, Ritt, DA

Mol. Cell 2005
21779496 Raf family kinases: old dogs have learned new tricks

Romano, D, Matallanas, D, Rauch, J, Zebisch, A, Birtwistle, M, Kolch, W, von Kriegsheim, A

Genes Cancer 2011
Participants
Participates
Catalyst Activity

protein serine/threonine phosphatase activity of PP2A [cytosol]

This event is regulated
Orthologous Events
Authored
Reviewed
Created
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