Reactome | Hydrolysis of PIP3 to PI(3,4)P2

Hydrolysis of PIP3 to PI(3,4)P2

Stable Identifier

R-HSA-202237

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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After the generation of PIP3 by PI3K, a part of it is further dephosphorylated to generate other forms of PI which are also involved in signaling. Two major routes for the degradation of PIP3 exists: dephosphorylation by the haematopoietic-specific SH2 domain-containing inositol 5' phosphatase SHIP-1 and dephosphorylation by the 3' phosphoinositide phosphatase PTEN.
SHIP-1 appears to set an activation threshold on T cell signaling. SHIP-1 phosphatase activity removes the 5' phosphate of PIP3 and generate phosphatidylinositol 3,4-bisphosphate. PI(3,4)P2 along with PIP3 preferentially binds to the PH domains of PKB and PDK1.

Literature References

PubMed ID	Title	Journal	Year
11884229	Regulation of the immune response by SHIP March, ME, Ravichandran, K	Semin Immunol	2002
10716940	Structure, function, and biology of SHIP proteins Rohrschneider, LR, Fuller, JF, Wolf, I, Liu, Y, Lucas, DM	Genes Dev	2000