SYNJ hydrolyze PI(4,5)P2 to PI(4)P

Stable Identifier
Reaction [transition]
Homo sapiens
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Inositol-5-phosphatases like SYNJs and OCRL hydrolyze PI(4,5)P2 to PI(4)P. In the context of CME, this promotes the abortive turnover (disassembly) of some CCPs, contributes to the dynamin-mediated scission of the clathrin-coated vesicle neck, and promotes clathrin uncoating following scission (Guan et al, 2010; Cremona et al, 1999; Mani et al, 2007; Chang-Ileto et al, 2011; Antonescu et al, 2011; reviewed in McMahon and Boucrot, 2011; Daumke et al, 2014).
Literature References
PubMed ID Title Journal Year
18093523 The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals

Ryan, TA, Cremona, O, Di Paolo, G, Mani, M, Lucast, L, De Camilli, P, Lee, SY

Neuron 2007
21779028 Molecular mechanism and physiological functions of clathrin-mediated endocytosis

Boucrot, E, McMahon, HT

Nat. Rev. Mol. Cell Biol. 2011
21613550 Phosphatidylinositol-(4,5)-bisphosphate regulates clathrin-coated pit initiation, stabilization, and size

Aguet, F, Antonescu, CN, Danuser, G, Schmid, SL

Mol. Biol. Cell 2011
20826345 Structure of the PTEN-like region of auxilin, a detector of clathrin-coated vesicle budding

Kirchhausen, T, Han, D, Guan, R, Harrison, SC, Dai, H

Structure 2010
24581490 BAR domain scaffolds in dynamin-mediated membrane fission

Daumke, O, Haucke, V, Roux, A

Cell 2014
10535736 Essential role of phosphoinositide metabolism in synaptic vesicle recycling

Flavell, RA, Cremona, O, Takei, K, Wenk, MR, Nemoto, Y, McCormick, DA, Di Paolo, G, Daniell, L, L├╝thi, A, De Camilli, P, Shears, SB, Kim, WT

Cell 1999
Catalyst Activity

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity of PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane]

Orthologous Events
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