PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane

Stable Identifier
R-HSA-1676204
Type
Reaction
Species
Homo sapiens
Compartment
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At the Golgi membrane, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase (TPTE2) aka TPIP dephosphorylates phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) to produce phosphatidylinositol 4-phosphate (PI4P) (Tapparel et al. 2000, Walker et al. 2001). The transmembrane phosphatase TPTE2 gamma isoform colocalises in the Golgi and the endoplasmic reticulum (Tapparel et al. 2000).

Literature References
PubMed ID Title Journal Year
11716755 TPIP: a novel phosphoinositide 3-phosphatase

Leslie, NR, Walker, SM, Downes, CP

Biochem J 2001
14659893 The TPTE gene family: cellular expression, subcellular localization and alternative splicing

Lyle, R, Tapparel, C, Antonarakis, SE, Guillou, L, Hutter, P, Reymond, A, Lamon, C, Girardet, C

Gene 2003
Participants
Participates
Catalyst Activity

phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity of TPTE2-like proteins [Golgi membrane]

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