Reactome | PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane

PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane

Stable Identifier

R-HSA-1676204

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, cytosol

ReviewStatus

5/5

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PI(3,4)P2 is dephosphorylated to PI4P by TPTE2 at the Golgi membrane

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At the Golgi membrane, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase (TPTE2) aka TPIP dephosphorylates phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) to produce phosphatidylinositol 4-phosphate (PI4P) (Tapparel et al. 2000, Walker et al. 2001). The transmembrane phosphatase TPTE2 gamma isoform colocalises in the Golgi and the endoplasmic reticulum (Tapparel et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
11716755	TPIP: a novel phosphoinositide 3-phosphatase Leslie, NR, Walker, SM, Downes, CP	Biochem J	2001
14659893	The TPTE gene family: cellular expression, subcellular localization and alternative splicing Lyle, R, Tapparel, C, Antonarakis, SE, Guillou, L, Hutter, P, Reymond, A, Lamon, C, Girardet, C	Gene	2003