Reactome | AMPK is dephosphorylated

AMPK is dephosphorylated

Stable Identifier

R-HSA-380949

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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Normally under low AMP:ATP conditions, the active AMPK is dephosphorylated (possibly by PP2C), and thus inactivated.

Literature References

PubMed ID	Title	Journal	Year
16943194	Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase Suter, M, Riek, U, Tuerk, R, Schlattner, U, Wallimann, T, Neumann, D	J Biol Chem	2006
8549768	5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC Davies, SP, Helps, NR, Cohen, PT, Hardie, DG	FEBS Lett	1995