Reactome | AMPK is dephosphorylated

AMPK is dephosphorylated

Stable Identifier

R-HSA-380949

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Normally under low AMP:ATP conditions, the active AMPK is dephosphorylated (possibly by PP2C), and thus inactivated.

Literature References

PubMed ID	Title	Journal	Year
8549768	5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC Davies, SP, Hardie, DG, Helps, NR, Cohen, PT	FEBS Lett	1995
16943194	Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase Neumann, D, Tuerk, R, Wallimann, T, Suter, M, Schlattner, U, Riek, U	J Biol Chem	2006