Reactome | AMPK is dephosphorylated

AMPK is dephosphorylated

Stable Identifier

R-HSA-380949

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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Normally under low AMP:ATP conditions, the active AMPK is dephosphorylated (possibly by PP2C), and thus inactivated.

Literature References

PubMed ID	Title	Journal	Year
16943194	Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase Suter, M, Riek, U, Tuerk, R, Schlattner, U, Wallimann, T, Neumann, D	J Biol Chem	2006
8549768	5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC Davies, SP, Helps, NR, Cohen, PT, Hardie, DG	FEBS Lett	1995

Participants

Input

Output

Participant Of

hasEvent

Energy dependent regulation of mTOR by LKB1-AMPK

Catalyst Activity

Title

protein serine/threonine phosphatase activity of PPM1A [cytosol]

Physical Entity

PPM1A [cytosol]

Activity

protein serine/threonine phosphatase activity (0004722)

Orthologous Events

AMPK is dephosphorylated (Bos taurus)

AMPK is dephosphorylated (Caenorhabditis elegans)

AMPK is dephosphorylated (Canis familiaris)

AMPK is dephosphorylated (Danio rerio)

AMPK is dephosphorylated (Drosophila melanogaster)

AMPK is dephosphorylated (Gallus gallus)

AMPK is dephosphorylated (Mus musculus)

AMPK is dephosphorylated (Rattus norvegicus)

AMPK is dephosphorylated (Xenopus tropicalis)

Authored

Katajisto, P (2008-11-19)

Makela, T (2008-11-19)

Wu, J (2008-11-19)

Reviewed

Zwartkruis, FJ (2015-05-14)

Created

Jassal, B (2008-11-19)