Reactome | AMPK is dephosphorylated

AMPK is dephosphorylated

Stable Identifier

R-HSA-380949

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Normally under low AMP:ATP conditions, the active AMPK is dephosphorylated (possibly by PP2C), and thus inactivated.

Literature References

PubMed ID	Title	Journal	Year
8549768	5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC Davies, SP, Helps, NR, Cohen, PT, Hardie, DG	FEBS Lett	1995
16943194	Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase Suter, M, Riek, U, Tuerk, R, Schlattner, U, Wallimann, T, Neumann, D	J Biol Chem	2006