Inactivation of Rho-GTP by p190RhoGAP

Stable Identifier
R-HSA-416559
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Inactivation of Rho-GTP by p190RhoGAP
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
p190RhoGAP complexed with Plexin-B1 stimulates GTP hydrolysis by RhoA. The resulting lower levels of Rho-GTP may account for F-actin depolymerization and cytoskeletal rearrangements.
Literature References
PubMed ID Title Journal Year
16188938 p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling

Barberis, D, Casazza, A, Sordella, R, Corso, S, Artigiani, S, Settleman, J, Comoglio, PM, Tamagnone, L

J Cell Sci 2005
Participants
Input
Output
Participates
as an event of
Catalyst Activity

GTPase activator activity of SEMA4D:MET:p-Y-PLXNB1:RND1:GTP:ARHGAP35 [plasma membrane]

Physical Entity
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP:ARHGAP35 [plasma membrane] (Homo sapiens)
Activity
GTPase activator activity (GO:0005096)
Orthologous Events
Inactivation of Rho-GTP by p190RhoGAP (Bos taurus)
Inactivation of Rho-GTP by p190RhoGAP (Caenorhabditis elegans)
Inactivation of Rho-GTP by p190RhoGAP (Canis familiaris)
Inactivation of Rho-GTP by p190RhoGAP (Danio rerio)
Inactivation of Rho-GTP by p190RhoGAP (Gallus gallus)
Inactivation of Rho-GTP by p190RhoGAP (Mus musculus)
Inactivation of Rho-GTP by p190RhoGAP (Rattus norvegicus)
Inactivation of Rho-GTP by p190RhoGAP (Sus scrofa)
Inactivation of Rho-GTP by p190RhoGAP (Xenopus tropicalis)
Authored
Garapati, P V  (2009-03-23)
Reviewed
Kumanogoh, A  (2009-09-02)
Kikutani, H  (2009-09-02)
Created
Garapati, P V  (2009-03-30)
Cite Us!