Inactivation of Rho-GTP by p190RhoGAP

Stable Identifier
R-HSA-416559
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Inactivation of Rho-GTP by p190RhoGAP
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p190RhoGAP complexed with Plexin-B1 stimulates GTP hydrolysis by RhoA. The resulting lower levels of Rho-GTP may account for F-actin depolymerization and cytoskeletal rearrangements.

Literature References
PubMed ID Title Journal Year
16188938 p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling

Barberis, D, Casazza, A, Sordella, R, Corso, S, Artigiani, S, Settleman, J, Comoglio, PM, Tamagnone, L

J Cell Sci 2005
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
GTPase activator activity of SEMA4D:MET:p-Y-PLXNB1:RND1:GTP:ARHGAP35 [plasma membrane]
Physical Entity
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP:ARHGAP35 [plasma membrane]
Activity
GTPase activator activity (0005096)
Orthologous Events
Inactivation of Rho-GTP by p190RhoGAP (Bos taurus)
Inactivation of Rho-GTP by p190RhoGAP (Caenorhabditis elegans)
Inactivation of Rho-GTP by p190RhoGAP (Canis familiaris)
Inactivation of Rho-GTP by p190RhoGAP (Danio rerio)
Inactivation of Rho-GTP by p190RhoGAP (Gallus gallus)
Inactivation of Rho-GTP by p190RhoGAP (Mus musculus)
Inactivation of Rho-GTP by p190RhoGAP (Rattus norvegicus)
Inactivation of Rho-GTP by p190RhoGAP (Sus scrofa)
Inactivation of Rho-GTP by p190RhoGAP (Xenopus tropicalis)
Authored
Garapati, P V  (2009-03-23)
Reviewed
Kumanogoh, A  (2009-09-02)
Kikutani, H  (2009-09-02)
Created
Garapati, P V  (2009-03-30)