Inactivation of Rho-GTP by p190RhoGAP

Stable Identifier
R-HSA-416559
Type
Reaction
Species
Homo sapiens
Compartment
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p190RhoGAP complexed with Plexin-B1 stimulates GTP hydrolysis by RhoA. The resulting lower levels of Rho-GTP may account for F-actin depolymerization and cytoskeletal rearrangements.

Literature References
PubMed ID Title Journal Year
16188938 p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling

Artigiani, S, Sordella, R, Corso, S, Tamagnone, L, Barberis, D, Casazza, A, Comoglio, PM, Settleman, J

J Cell Sci 2005
Participants
Participates
Catalyst Activity

GTPase activator activity of SEMA4D:MET:p-Y-PLXNB1:RND1:GTP:ARHGAP35 [plasma membrane]

Orthologous Events
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Reviewed
Created
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