p190RhoGAP complexed with Plexin-B1 stimulates GTP hydrolysis by RhoA. The resulting lower levels of Rho-GTP may account for F-actin depolymerization and cytoskeletal rearrangements.
Barberis, D, Casazza, A, Sordella, R, Corso, S, Artigiani, S, Settleman, J, Comoglio, PM, Tamagnone, L
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