DOLPP1 dephosphorylates DOLDP to DOLP

Stable Identifier
R-HSA-446200
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In the last step of the N-glycan precursor biosynthesis pathway, the mature N-glycan (Glc3Man9GlcNAc2) is removed from the dolichyl diphosphate (DOLDP) molecule upon which it has been synthesized and attached to a nascent protein. The released DOLDP molecule is de-phosphorylated by dolichyl diphosphatase 1 (DOLPP1) to dolichyl phosphate (DOLP). DOLP is thus salvaged and be used as substrate for the synthesis of another N-glycan oligosaccharide (Wedgwood & Strominger 1980).

Literature References
PubMed ID Title Journal Year
6243292 Enzymatic activities in cultured human lymphocytes that dephosphorylate dolichyl pyrophosphate and dolichyl phosphate

Wedgwood, JF, Strominger, JL

J Biol Chem 1980
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
dolichyldiphosphatase activity of DOLPP1 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created