MTMR4 dephosphorylates SMAD2/3

Stable Identifier
R-HSA-2187401
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, early endosome membrane
ReviewStatus
5/5
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MTMR4 dephosphorylates SMAD2/3
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MTMR4 protein phosphatase dephosphorylates SMAD2 and SMAD3, preventing formation of SMAD2/3:SMAD4 heterotrimers and inhibiting transmission of TGF-beta signal to the nucleus (Yu et al. 2010).
Literature References
PubMed ID Title Journal Year
20061380 MTMR4 attenuates transforming growth factor beta (TGFbeta) signaling by dephosphorylating R-Smads in endosomes

Xu, Y, Yu, J, Chen, Y, Pan, L, Tang, H, Chen, H, Qin, X

J Biol Chem 2010
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as an event of
Catalyst Activity

protein serine/threonine phosphatase activity of p-2S-SMAD2/3:MTMR4 [early endosome membrane]

Physical Entity
p-2S-SMAD2/3:MTMR4 [early endosome membrane] (Homo sapiens)
Activity
protein serine/threonine phosphatase activity (GO:0004722)
Orthologous Events
MTMR4 dephosphorylates SMAD2/3 (Bos taurus)
MTMR4 dephosphorylates SMAD2/3 (Canis familiaris)
MTMR4 dephosphorylates SMAD2/3 (Drosophila melanogaster)
MTMR4 dephosphorylates SMAD2/3 (Gallus gallus)
MTMR4 dephosphorylates SMAD2/3 (Mus musculus)
MTMR4 dephosphorylates SMAD2/3 (Rattus norvegicus)
MTMR4 dephosphorylates SMAD2/3 (Sus scrofa)
MTMR4 dephosphorylates SMAD2/3 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2012-04-10)
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