MTMR4 dephosphorylates SMAD2/3

Stable Identifier
R-HSA-2187401
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MTMR4 protein phosphatase dephosphorylates SMAD2 and SMAD3, preventing formation of SMAD2/3:SMAD4 heterotrimers and inhibiting transmission of TGF-beta signal to the nucleus (Yu et al. 2010).

Literature References
PubMed ID Title Journal Year
20061380 MTMR4 attenuates transforming growth factor beta (TGFbeta) signaling by dephosphorylating R-Smads in endosomes

Yu, J, Pan, L, Qin, X, Chen, H, Xu, Y, Chen, Y, Tang, H

J Biol Chem 2010
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Catalyst Activity

protein serine/threonine phosphatase activity of p-2S-SMAD2/3:MTMR4 [early endosome membrane]

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