PTPN1 and PTPN2 dephosphorylate MET

Stable Identifier
R-HSA-6807027
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Protein tyrosine phosphatases PTPN1 (PTP1B) and PTPN2 (TCPTP) can dephosphorylate MET at tyrosine residues Y1234 and Y1235 in the activation loop of the MET kinase domain, resulting in the inhibition of MET catalytic activity (Sangwan et al. 2008).

Literature References
PubMed ID Title Journal Year
18819921 Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase

Sangwan, V, Paliouras, GN, Abella, JV, Dubé, N, Monast, A, Tremblay, ML, Park, M

J. Biol. Chem. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine phosphatase activity of PTPN1,PTPN2 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created