PTPN1 and PTPN2 dephosphorylate MET

Stable Identifier
R-HSA-6807027
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PTPN1 and PTPN2 dephosphorylate MET
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Protein tyrosine phosphatases PTPN1 (PTP1B) and PTPN2 (TCPTP) can dephosphorylate MET at tyrosine residues Y1234 and Y1235 in the activation loop of the MET kinase domain, resulting in the inhibition of MET catalytic activity (Sangwan et al. 2008).
Literature References
PubMed ID Title Journal Year
18819921 Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase

Sangwan, V, Monast, A, Dubé, N, Paliouras, GN, Abella, JV, Tremblay, ML, Park, M

J. Biol. Chem. 2008
Participants
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Output
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as an event of
Catalyst Activity

protein tyrosine phosphatase activity of PTPN1,PTPN2 [cytosol]

Physical Entity
PTPN1,PTPN2 [cytosol] (Homo sapiens)
Activity
protein tyrosine phosphatase activity (GO:0004725)
Orthologous Events
PTPN1 and PTPN2 dephosphorylate MET (Bos taurus)
PTPN1 and PTPN2 dephosphorylate MET (Canis familiaris)
PTPN1 and PTPN2 dephosphorylate MET (Gallus gallus)
PTPN1 and PTPN2 dephosphorylate MET (Mus musculus)
PTPN1 and PTPN2 dephosphorylate MET (Rattus norvegicus)
PTPN1 and PTPN2 dephosphorylate MET (Sus scrofa)
PTPN1 and PTPN2 dephosphorylate MET (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Birchmeier, W  (2016-07-11)
Heynen, G  (2016-07-11)
Created
Orlic-Milacic, M  (2015-10-28)
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