PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate

Stable Identifier
R-HSA-70262
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate
ReviewStatus
5/5
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PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate
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The fructose 2,6-bisphosphatase activity of cytosolic phosphofructokinase 2/fructose-2,6-bisphosphatase catalyzes the hydrolysis of fructose 2,6 bisphosphate to form fructose 6-phosphate. Fructose 2,6 bisphosphate is a key allosteric regulator of PFK1. In its absence the activity of PFK1 is reduced while fructose 1,6-bisphosphatase is activated, thus inhibiting glycolysis and favoring gluconeogenesis (Pilkis et al. 1995).
Literature References
PubMed ID Title Journal Year
7574501 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme.

Pilkis, SJ, Claus, TH, Kurland, IJ, Lange, AJ

Annu Rev Biochem 1995
Participants
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Output
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as an event of
Event Information
Go Biological Process
negative regulation of glycolytic process (0045820)
Catalyst Activity

fructose-2,6-bisphosphate 2-phosphatase activity of p-PFKFB1 dimer [cytosol]

Physical Entity
p-PFKFB1 dimer [cytosol] (Homo sapiens)
Activity
fructose-2,6-bisphosphate 2-phosphatase activity (GO:0004331)
Orthologous Events
PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate (Bos taurus)
PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate (Caenorhabditis elegans)
PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate (Canis familiaris)
PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate (Danio rerio)
PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate (Dictyostelium discoideum)
PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate (Drosophila melanogaster)
PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate (Gallus gallus)
PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate (Mus musculus)
PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate (Rattus norvegicus)
PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate (Saccharomyces cerevisiae)
PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate (Schizosaccharomyces pombe)
PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate (Sus scrofa)
PFKFKB dimer dephosphorylates fructose 2,6-bisphosphate (Xenopus tropicalis)
Cross References
RHEA
Reviewed
Harris, RA  (2008-09-10)
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