Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate

Stable Identifier
R-HSA-70262
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate
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The fructose 2,6-bisphosphatase activity of cytosolic phosphofructokinase 2/fructose-2,6-bisphosphatase catalyzes the hydrolysis of fructose 2,6 bisphosphate to form fructose 6-phosphate. Fructose 2,6 bisphosphate is a key allosteric regulator of PFK1. In its absence the activity of PFK1 is reduced while fructose 1,6-bisphosphatase is activated, thus inhibiting glycolysis and favoring gluconeogenesis (Pilkis et al. 1995).
Literature References
PubMed ID Title Journal Year
7574501 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme.

Kurland, IJ, Lange, AJ, Pilkis, SJ, Claus, TH

Annu Rev Biochem 1995
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as an event of
Event Information
Go Biological Process
negative regulation of glycolytic process (0045820)
Catalyst Activity

fructose-2,6-bisphosphate 2-phosphatase activity of phosphoPFKFB1 dimer [cytosol]

Physical Entity
phosphoPFKFB1 dimer [cytosol] (Homo sapiens)
Activity
fructose-2,6-bisphosphate 2-phosphatase activity (GO:0004331)
Orthologous Events
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Bos taurus)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Caenorhabditis elegans)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Canis familiaris)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Dictyostelium discoideum)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Drosophila melanogaster)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Gallus gallus)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Mus musculus)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Rattus norvegicus)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Saccharomyces cerevisiae)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Schizosaccharomyces pombe)
Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate (Sus scrofa)
Cross References
Rhea
Reviewed
Harris, RA  (2008-09-10)
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