Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate

Stable Identifier
R-HSA-70262
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The fructose 2,6-bisphosphatase activity of cytosolic phosphofructokinase 2/fructose-2,6-bisphosphatase catalyzes the hydrolysis of fructose 2,6 bisphosphate to form fructose 6-phosphate. Fructose 2,6 bisphosphate is a key allosteric regulator of PFK1. In its absence the activity of PFK1 is reduced while fructose 1,6-bisphosphatase is activated, thus inhibiting glycolysis and favoring gluconeogenesis (Pilkis et al. 1995).

Literature References
PubMed ID Title Journal Year
7574501 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme.

Pilkis, SJ, Claus, TH, Kurland, IJ, Lange, AJ

Annu Rev Biochem 1995
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
fructose-2,6-bisphosphate 2-phosphatase activity of phosphoPFKFB1 dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Reviewed