4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane

Stable Identifier
R-HSA-216757
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
ABCA1-mediated transport of intracellular phospholipid to the cell surface
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In an ATP-dependent reaction, ATPA1 mediates the movement of intracellular phospholipid to the extracellular face of the plasma membrane. Cholesterol associated with cytosolic vesicles is a substrate for this reaction. Under physiologocal conditions, the active form of ABCA1 is predominantly a tetramer associated with apolipoprotein A-I (APOA1) (Denis et al. 2004, Vedhachalam et al. 2007). The number of lipid molecules transported per ATP consumed is not known.

Literature References
PubMed ID Title Journal Year
17604270 Mechanism of ATP-binding cassette transporter A1-mediated cellular lipid efflux to apolipoprotein A-I and formation of high density lipoprotein particles

Vedhachalam, C, Duong, PT, Nickel, M, Nguyen, D, Dhanasekaran, P, Saito, H, Rothblat, GH, Lund-Katz, S, Phillips, MC

J Biol Chem 2007
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
phospholipid transporter activity of 4xPALM-C-p-2S-ABCA1 tetramer:APOA1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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