4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane

Stable Identifier
R-HSA-216757
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
ABCA1-mediated transport of intracellular phospholipid to the cell surface
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In an ATP-dependent reaction, ATPA1 mediates the movement of intracellular phospholipid to the extracellular face of the plasma membrane. Cholesterol associated with cytosolic vesicles is a substrate for this reaction. Under physiologocal conditions, the active form of ABCA1 is predominantly a tetramer associated with apolipoprotein A-I (APOA1) (Denis et al. 2004, Vedhachalam et al. 2007). The number of lipid molecules transported per ATP consumed is not known.
Literature References
PubMed ID Title Journal Year
17604270 Mechanism of ATP-binding cassette transporter A1-mediated cellular lipid efflux to apolipoprotein A-I and formation of high density lipoprotein particles

Nickel, M, Saito, H, Duong, PT, Phillips, MC, Rothblat, GH, Dhanasekaran, P, Nguyen, D, Lund-Katz, S, Vedhachalam, C

J Biol Chem 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

phospholipid transporter activity of 4xPALM-C-p-2S-ABCA1 tetramer:APOA1 [plasma membrane]

Physical Entity
4xPALM-C-p-2S-ABCA1 tetramer:APOA1 [plasma membrane] (Homo sapiens)
Activity
phospholipid transporter activity (GO:0005548)
Orthologous Events
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Bos taurus)
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Canis familiaris)
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Danio rerio)
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Gallus gallus)
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Mus musculus)
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Rattus norvegicus)
4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane (Sus scrofa)
Authored
D'Eustachio, P  (2008-05-12)
Reviewed
Jassal, B  (2008-06-13)
Created
D'Eustachio, P  (2008-03-22)
Cite Us!