Reactome | Ribosomal scanning

Ribosomal scanning

Stable Identifier

R-HSA-72621

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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The mRNA-bound ribosomal complex moves along the 5'-untranslated region (5'-UTR) of the mRNA from its initial site to the initiation codon to form a 48S complex, in which the initiation codon (AUG) is base paired to the anticodon of the Met-tRNAi. It is not known whether eIF4A (or another ATPase, such as DED1) facilitates scanning by melting mRNA secondary structures or by actively propelling the ribosome.

Literature References

PubMed ID	Title	Journal	Year
10364207	Ded1p, a DEAD-box protein required for translation initiation in Saccharomyces cerevisiae, is an RNA helicase. Iost, I, Dreyfus, M, Linder, P	J Biol Chem	1999
592399	Initiation of mammalian protein synthesis. II. The assembly of the initiation complex with purified initiation factors. Trachsel, H, Erni, B, Schreier, MH, Staehelin, T	J Mol Biol	1978
9045610	Requirement of the DEAD-Box protein ded1p for messenger RNA translation. Chuang, RY, Weaver, PL, Liu, Z, Chang, TH	Science	1997
641056	The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes. Benne, R, Hershey, JW	J Biol Chem	1978
8943342	Functional dissection of eukaryotic initiation factor 4F: the 4A subunit and the central domain of the 4G subunit are sufficient to mediate internal entry of 43S preinitiation complexes. Pestova, TV, Shatsky, IN, Hellen, CU	Mol Cell Biol	1997
7000367	Evaluation of the "scanning model" for initiation of protein synthesis in eucaryotes. Kozak, M	Cell	1981