PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane

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R-HSA-1676141
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Reaction
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Homo sapiens
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At the early endosome membrane, myotubularin (MTM1), myotubularin-related protein 2 (MTMR2), and myotubularin-related protein 4 (MTMR4) dephosphorylate phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol (PI).

The following lists the above proteins with their corresponding literature references: MTM1 (Cao et al. 2007, Cao et al. 2008, Kim et al. 2002), MTMR2 (Cao et al. 2008, Kim et al. 2002), and MTMR4 (Lorenzo et al. 2006, Zhao et al. 2001).

Literature References
PubMed ID Title Journal Year
16787938 Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions

Lorenzo, O, Clague, MJ, Urbé, S

J Cell Sci 2006
11302699 FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphotidylinositol 3-phosphate

Zhao, R, Zhao, ZJ, Chen, J, Qi, Y

Exp Cell Res 2001
18524850 Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking

Bedrick, EJ, Wandinger-Ness, A, Cao, C, Laporte, J, Backer, JM

Mol Biol Cell 2008
17651088 Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes

Wandinger-Ness, A, Cao, C, Laporte, J, Stein, MP, Backer, JM

Traffic 2007
11733541 Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease

Taylor, GS, Torgersen, KM, Kim, SA, Dixon, JE

J Biol Chem 2002
Participants
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Catalyst Activity

phosphatidylinositol-3-phosphatase activity of MTM1,MTMR2,MTMR4 [cytosol]

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