PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane

Stable Identifier
Reaction [transition]
Homo sapiens
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At the early endosome membrane, myotubularin (MTM1), myotubularin-related protein 2 (MTMR2) and myotubularin-related protein 4 (MTMR4) dephosphorylate phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 5-phosphate (PI5P).

The following lists the above proteins with their corresponding literature references: MTM1 (Cao et al. 2007, Cao et al. 2008), MTMR2 (Cao et al. 2008), and MTMR4 (Lorenzo et al. 2006).

Literature References
PubMed ID Title Journal Year
16787938 Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions

Lorenzo, O, Clague, MJ, Urbé, S

J Cell Sci 2006
17651088 Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes

Wandinger-Ness, A, Cao, C, Laporte, J, Stein, MP, Backer, JM

Traffic 2007
18524850 Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking

Bedrick, EJ, Wandinger-Ness, A, Cao, C, Laporte, J, Backer, JM

Mol Biol Cell 2008
Catalyst Activity

phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity of MTM1,MTMR2,MTMR4 [cytosol]

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