Reactome | Internalization of MHC II:Ii clathrin coated vesicle

Internalization of MHC II:Ii clathrin coated vesicle

Stable Identifier

R-HSA-2130725

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, clathrin-coated endocytic vesicle membrane

ReviewStatus

5/5

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Internalization of MHC II:Ii clathrin coated vesicle

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MHC II:Ii complexes are internalized in to the endocytic clathrin coated-pit. Dynamin, the GTPase involved in the scission of clathrin-coated vesicles from plasma membrane is observed to be involved in the effective endocytosis of MHC II:Ii complexes. Wang et al, demonstrated that overexpression of a dominant-negative mutant of the GTPase dynamin resulted in the cell surface accumulation of MHC II:Ii complex, supporting that endocytosis is required for delivery to antigen processing compartments (Wang et al, 1997). However, another study using the same dynamin mutant generated opposite conclusions (Davidson, 1999). This discrepancy may be caused by differences in experimental set-up and in the levels of expression of the dynamin mutant and MHC II chains (Dugast et al, 2005).

Literature References

PubMed ID	Title	Journal	Year
15749704	AP2 clathrin adaptor complex, but not AP1, controls the access of the major histocompatibility complex (MHC) class II to endosomes Dugast, M, Toussaint, H, Dousset, C, Benaroch, P	J Biol Chem	2005
8397411	Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization Roche, PA, Teletski, CL, Stang, E, Bakke, O, Long, EO	Proc Natl Acad Sci U S A	1993
10480952	Direct transport of newly synthesized HLA-DR from the trans-Golgi network to major histocompatibility complex class II containing compartments (MIICS) demonstrated using a novel tyrosine-sulfated chimera Davidson, HW	J Biol Chem	1999
9202021	Decreased endosomal delivery of major histocompatibility complex class II-invariant chain complexes in dynamin-deficient cells Wang, K, Peterson, PA, Karlsson, L	J Biol Chem	1997