Reactome | FGAM + ATP => AIR + ADP + Pi

FGAM + ATP => AIR + ADP + Pi

Stable Identifier

R-HSA-73810

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

5'-phosphoribosylformylglycinamidine (FGAM) + ATP => 5'-phosphoribosyl-5-aminoimidazole (AIR) + ADP + orthophosphate

ReviewStatus

5/5

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The irreversible synthesis of cytosolic 5'-phosphoribosyl-5-aminoimidazole (AIR) from 5'-phosphoribosylformylglycinamidine (FGAM), accompanied by the conversion of ATP to ADP and orthophosphate, is catalyzed by the phosphoribosylaminoimidazole synthetase domain of the trifunctional protein, "phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase" (GART) (Aimi et al. 1990). The active form of the protein is cytosolic and may co-localize with other enzymes of de novo IMP biosynthesis under some metabolic conditions (Gooljarsingh et al. 2001; An et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
2147474	De novo purine nucleotide biosynthesis: cloning of human and avian cDNAs encoding the trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase by functional complementation in E. coli Qiu, H, Zalkin, H, Aimi, J, Williams, J, Dixon, JE	Nucleic Acids Res	1990
18388293	Reversible compartmentalization of de novo purine biosynthetic complexes in living cells Benkovic, SJ, Sheets, ED, Kumar, R, An, S	Science	2008
11381136	Localization of GAR transformylase in Escherichia coli and mammalian cells Benkovic, SJ, Gilroy, S, Gooljarsingh, LT, Ramcharan, J	Proc Natl Acad Sci USA	2001