TTL ligates L-Tyr to the carboxy terminus of alpha-tubulin

Stable Identifier
R-BTA-8955724
Type
Reaction [transition]
Species
Bos taurus
Compartment
General
SVG |   | PPTX  | SBGN
TTL ligates L-Tyr to the carboxy terminus of alpha-tubulin

TTL (tubulin tyrosine ligase) ligates tyrosine (L-Tyr) to the carboxy terminus of the alpha-tubulin subunit of an alpha tubulin:beta tubulin dimer in an ATP-dependent reaction. The reaction mechanism has been worked out with bovine proteins, as annotated here (Deans et al. 1992), and structural studies that demonstrate the basis of the enzyme's specificity for the carboxy terminus of tubulin alpha chains have been carried out with chicken proteins (Prota et al. 2013).

Literature References
PubMed ID Title Journal Year
1520276 Steady-state kinetic mechanism of bovine brain tubulin: tyrosine ligase

Deans, NL, Allison, RD, Purich, DL

Biochem. J. 1992
23358242 Structural basis of tubulin tyrosination by tubulin tyrosine ligase

Prota, AE, Magiera, MM, Kuijpers, M, Bargsten, K, Frey, D, Wieser, M, Jaussi, R, Hoogenraad, CC, Kammerer, RA, Janke, C, Steinmetz, MO

J. Cell Biol. 2013
Participants
Catalyst Activity
Catalyst Activity
Title
tubulin-tyrosine ligase activity of TTL [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created