uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]

Stable Identifier
R-HSA-74372
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]
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Cytosolic uridine phosphorylase (isoforms UPP1 and UPP2) catalyzes the reversible reactions of uracil with ribose 1-phosphate or deoxyribose 1-phosphate to yield uridine or deoxyuridine and orthophosphate (Watanabe and Uchida 1995; Johansson, 2003). The active form of UPP1 is a dimer (Rooslid et al. 2009).

Literature References
PubMed ID Title Journal Year
19291308 Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy

Roosild, TP, Castronovo, S, Fabbiani, M, Pizzorno, G

BMC Struct Biol 2009
7488099 Cloning and expression of human uridine phosphorylase

Watanabe, SI, Uchida, T

Biochem Biophys Res Commun 1995
12849978 Identification of a novel human uridine phosphorylase

Johansson, M

Biochem Biophys Res Commun 2003
Participants
Input
Output
Participant Of
hasEvent
Event Information
Reverse Reaction
(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP) (Homo sapiens)
Catalyst Activity
Catalyst Activity
Title
uridine phosphorylase activity of UPP1, UPP2 [cytosol]
Physical Entity
UPP1, UPP2 [cytosol]
Activity
uridine phosphorylase activity (0004850)
Orthologous Events
uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Bos taurus)
uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Caenorhabditis elegans)
uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Canis familiaris)
uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Danio rerio)
uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Drosophila melanogaster)
uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Gallus gallus)
uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Mus musculus)
uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Rattus norvegicus)
uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Sus scrofa)
uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] (Xenopus tropicalis)
Created
D'Eustachio, P  (2003-07-18)