Reactome | uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]

uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]

Stable Identifier

R-HSA-74372

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic uridine phosphorylase (isoforms UPP1 and UPP2) catalyzes the reversible reactions of uracil with ribose 1-phosphate or deoxyribose 1-phosphate to yield uridine or deoxyuridine and orthophosphate (Watanabe and Uchida 1995; Johansson, 2003). The active form of UPP1 is a dimer (Rooslid et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
7488099	Cloning and expression of human uridine phosphorylase Uchida, T, Watanabe, SI	Biochem Biophys Res Commun	1995
19291308	Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy Fabbiani, M, Roosild, TP, Pizzorno, G, Castronovo, S	BMC Struct Biol	2009
12849978	Identification of a novel human uridine phosphorylase Johansson, M	Biochem Biophys Res Commun	2003