Dephosphorylation of STAT1 by SHP2

Stable Identifier
R-HSA-997309
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Dephosphorylation of STAT1 by SHP2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SHP2 negatively regulates the IFN-induced JAK-STAT pathway by dephosphorylating STAT1 on Y701.
Literature References
PubMed ID Title Journal Year
18508557 Protein tyrosine phosphatases in the JAK/STAT pathway

Xu, D, Qu, CK

Front Biosci 2008
10022928 Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway

You, M, Yu, DH, Feng, GS

Mol Cell Biol 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine phosphatase activity of PTPN11 [cytosol]

Physical Entity
PTPN11 [cytosol] (Homo sapiens)
Activity
protein tyrosine phosphatase activity (GO:0004725)
Orthologous Events
Dephosphorylation of STAT1 by SHP2 (Bos taurus)
Dephosphorylation of STAT1 by SHP2 (Canis familiaris)
Dephosphorylation of STAT1 by SHP2 (Gallus gallus)
Dephosphorylation of STAT1 by SHP2 (Mus musculus)
Dephosphorylation of STAT1 by SHP2 (Rattus norvegicus)
Dephosphorylation of STAT1 by SHP2 (Sus scrofa)
Authored
Garapati, P V  (2010-07-07)
Reviewed
Abdul-Sater, AA  (2010-08-17)
Schindler, C  (2010-08-17)
Created
Garapati, P V  (2010-11-09)
Cite Us!