SEPHS2 phosphorylates H2Se to form SELP

Stable Identifier
R-HSA-8959510
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Selenoproteins are proteins that incorporate the nonstandard amino acid selenocysteine (Sec) in response to the UGA codon. Sec is synthesised in several steps from hydrogen selenide (H2Se), an intermediate formed from dietary sources of selenium. In the first step, cytosolic selenide water dikinase 2 (SEPHS2 aka SPS2) mediates the phosphorylation of H2Se using ATP as the phosphate donor, forming selenophosphate (SELP) (Tamura et al. 2004).

Literature References
PubMed ID Title Journal Year
15534230 Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation

Tamura, T, Yamamoto, S, Takahata, M, Sakaguchi, H, Tanaka, H, Stadtman, TC, Inagaki, K

Proc. Natl. Acad. Sci. U.S.A. 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
selenide, water dikinase activity of SEPHS2 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created