Selenoproteins are proteins that incorporate the nonstandard amino acid selenocysteine (Sec) in response to the UGA codon. Sec is synthesised in several steps from hydrogen selenide (H2Se), an intermediate formed from dietary sources of selenium. In the first step, cytosolic selenide water dikinase 2 (SEPHS2 aka SPS2) mediates the phosphorylation of H2Se using ATP as the phosphate donor, forming selenophosphate (SELP) (Tamura et al. 2004).
Stadtman, TC, Tamura, T, Sakaguchi, H, Takahata, M, Tanaka, H, Yamamoto, S, Inagaki, K
selenide, water dikinase activity of SEPHS2 [cytosol]
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