Reactome | TBC1D16 accelerates GTP hydrolysis by RAB4A

TBC1D16 accelerates GTP hydrolysis by RAB4A

Stable Identifier

R-HSA-8854604

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytoplasmic vesicle membrane

ReviewStatus

5/5

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TBC1D16 accelerates GTP hydrolysis by RAB4A

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RAB4A is a master regulator of receptor recycling from endocytic compartments to the plasma membrane. It is involved in transferrin receptor recycling and EGFR trafficking and signalling. TBC (Tre2/Bub2/Cdc16) domain family member 16 (TBC1D16), is a GTPase activating protein for Rab4A and enhances the intrinsic rate of GTP hydrolysis by RAB4A (Goueli et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
23019362	TBC1D16 is a Rab4A GTPase activating protein that regulates receptor recycling and EGF receptor signaling Goueli, BS, Pfeffer, SR, Finger, EC, Powell, MB	Proc. Natl. Acad. Sci. U.S.A.	2012