TBC1D16 accelerates GTP hydrolysis by RAB4A

Stable Identifier
R-HSA-8854604
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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RAB4A is a master regulator of receptor recycling from endocytic compartments to the plasma membrane. It is involved in transferrin receptor recycling and EGFR trafficking and signalling. TBC (Tre2/Bub2/Cdc16) domain family member 16 (TBC1D16), is a GTPase activating protein for Rab4A and enhances the intrinsic rate of GTP hydrolysis by RAB4A (Goueli et al. 2012).

Literature References
PubMed ID Title Journal Year
23019362 TBC1D16 is a Rab4A GTPase activating protein that regulates receptor recycling and EGF receptor signaling

Goueli, BS, Powell, MB, Finger, EC, Pfeffer, SR

Proc. Natl. Acad. Sci. U.S.A. 2012
Participants
Participates
Catalyst Activity

GTPase activity of GGC-RAB4A:GTP [cytoplasmic vesicle membrane]

This event is regulated
Positively by
Regulator
Summation

RAB4A is a master regulator of receptor recycling from endocytic compartments to the plasma membrane. It is involved in transferrin receptor recycling and EGFR trafficking and signalling. TBC (Tre2/Bub2/Cdc16) domain family member 16 (TBC1D16), is a GTPase activating protein for Rab4A and enhances the intrinsic rate of GTP hydrolysis by RAB4A (Goueli et al. 2012).

Orthologous Events
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