PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate

Stable Identifier
R-HSA-428696
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]
ReviewStatus
5/5
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Phospholipid phosphatases 1 (PLPP1, PPAP2A, LPP1), 2 (PLPP2, LPP2, PPAP2C), and 3 (PLPP3, LPP3, PPAP2B) associated with the plasma membrane catalyze the hydrolysis of cytosolic sphingosine 1-phosphate to form sphingosine and orthophosphate (Roberts et al. 1998). PLPPs have roles in angiogenesis and cancer (reviewed by Tang et al., 2015; Tang & Brindley, 2020).

Literature References
PubMed ID Title Journal Year
32887262 Lipid Phosphate Phosphatases and Cancer

Tang, X, Brindley, DN

Biomolecules 2020
9705349 Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform.

Morris, AJ, Roberts, R, Sciorra, VA

J Biol Chem 1998
25814022 Lipid phosphate phosphatases and their roles in mammalian physiology and pathology

Tang, X, Benesch, MG, Brindley, DN

J Lipid Res 2015
Participants
Participates
Catalyst Activity

sphingosine-1-phosphate phosphatase activity of PLPP1,2,3 [plasma membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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