Reactome | PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate

PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate

Stable Identifier

R-HSA-428696

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Synonyms

sphingosine 1-phosphate + H2O => sphingosine + orthophosphate [cytosolic - PPAP]

ReviewStatus

5/5

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PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate

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Phospholipid phosphatases 1 (PLPP1, PPAP2A, LPP1), 2 (PLPP2, LPP2, PPAP2C), and 3 (PLPP3, LPP3, PPAP2B) associated with the plasma membrane catalyze the hydrolysis of cytosolic sphingosine 1-phosphate to form sphingosine and orthophosphate (Roberts et al. 1998). PLPPs have roles in angiogenesis and cancer (reviewed by Tang et al., 2015; Tang & Brindley, 2020).

Literature References

PubMed ID	Title	Journal	Year
32887262	Lipid Phosphate Phosphatases and Cancer Tang, X, Brindley, DN	Biomolecules	2020
9705349	Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform. Roberts, R, Sciorra, VA, Morris, AJ	J Biol Chem	1998
25814022	Lipid phosphate phosphatases and their roles in mammalian physiology and pathology Tang, X, Benesch, MG, Brindley, DN	J Lipid Res	2015