Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites

Stable Identifier
R-HSA-416639
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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GluR2 containing AMPA receptors are trafficked to the plasmamembrane by the activation of Ca activated PKC that binds PICK.The PICK interaction delivers GluR2 containing AMPA receptors to the Plasmamembrane. This reaction is a part of constitutive recycling of AMPA receptor that delivers the AMPA receptors from the endosome to the plasmamembrane and back to endosome from the plasmamembrane.

Literature References
PubMed ID Title Journal Year
16055064 PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking

Lu, W, Ziff, EB

Neuron 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
calcium-dependent protein kinase C activity of Activated conventional protein kinase C [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created